Evaluation of tear osmolarity measured by I-Pen osmolarity system in patients with dry eye

Abstract This retrospective comparative study was to evaluate tear osmolarity measured by I-Pen osmolarity system (I-MED Pharma Inc, Dollard-des-Ormeaux, Quebec, Canada) in healthy subjects without dry eye disease (DED) and patients with DED, and its association with other ocular surface parameters....

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Autores principales:	Jongyeop Park, Youngjoo Choi, Gyule Han, Eunhae Shin, Jisang Han, Tae-Young Chung, Dong Hui Lim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/345b512794bd4be185cdd300f187e586
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spelling	oai:doaj.org-article:345b512794bd4be185cdd300f187e5862021-12-02T14:15:53ZEvaluation of tear osmolarity measured by I-Pen osmolarity system in patients with dry eye10.1038/s41598-021-87336-22045-2322https://doaj.org/article/345b512794bd4be185cdd300f187e5862021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87336-2https://doaj.org/toc/2045-2322Abstract This retrospective comparative study was to evaluate tear osmolarity measured by I-Pen osmolarity system (I-MED Pharma Inc, Dollard-des-Ormeaux, Quebec, Canada) in healthy subjects without dry eye disease (DED) and patients with DED, and its association with other ocular surface parameters. This study comprised 65 eyes of 65 patients. The ocular surface parameters including tear osmolarity with I-Pen osmometer of the patients who visited the refractive surgery center of Samsung Medical Center between January 1, 2020 and May 31, 2020 were retrospectively collected. The subjects were divided as asymptomatic normal group and symptomatic dry eye group. The distribution of tear osmolarity and its association with other ocular surface parameters were evaluated. Total thirty-two patients (32 eyes) were included in the control group, and 33 patients (33 eyes) were included in the DED group. Tear osmolarity was significantly higher in the DED group. Tear osmolarity was negatively correlated with tear break-up time, and the Schirmer test, and was positively correlated with Ocular Surface Disease Index symptom score. The cut-off value of 318 mOsm/L showed a sensitivity of 90.9% and specificity of 90.6% for diagnosing DED. The I-Pen osmometer can be considered suitable for use in the clinical setting, with good performance in DED diagnosis.Jongyeop ParkYoungjoo ChoiGyule HanEunhae ShinJisang HanTae-Young ChungDong Hui LimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jongyeop Park Youngjoo Choi Gyule Han Eunhae Shin Jisang Han Tae-Young Chung Dong Hui Lim Evaluation of tear osmolarity measured by I-Pen osmolarity system in patients with dry eye
description	Abstract This retrospective comparative study was to evaluate tear osmolarity measured by I-Pen osmolarity system (I-MED Pharma Inc, Dollard-des-Ormeaux, Quebec, Canada) in healthy subjects without dry eye disease (DED) and patients with DED, and its association with other ocular surface parameters. This study comprised 65 eyes of 65 patients. The ocular surface parameters including tear osmolarity with I-Pen osmometer of the patients who visited the refractive surgery center of Samsung Medical Center between January 1, 2020 and May 31, 2020 were retrospectively collected. The subjects were divided as asymptomatic normal group and symptomatic dry eye group. The distribution of tear osmolarity and its association with other ocular surface parameters were evaluated. Total thirty-two patients (32 eyes) were included in the control group, and 33 patients (33 eyes) were included in the DED group. Tear osmolarity was significantly higher in the DED group. Tear osmolarity was negatively correlated with tear break-up time, and the Schirmer test, and was positively correlated with Ocular Surface Disease Index symptom score. The cut-off value of 318 mOsm/L showed a sensitivity of 90.9% and specificity of 90.6% for diagnosing DED. The I-Pen osmometer can be considered suitable for use in the clinical setting, with good performance in DED diagnosis.
format	article
author	Jongyeop Park Youngjoo Choi Gyule Han Eunhae Shin Jisang Han Tae-Young Chung Dong Hui Lim
author_facet	Jongyeop Park Youngjoo Choi Gyule Han Eunhae Shin Jisang Han Tae-Young Chung Dong Hui Lim
author_sort	Jongyeop Park
title	Evaluation of tear osmolarity measured by I-Pen osmolarity system in patients with dry eye
title_short	Evaluation of tear osmolarity measured by I-Pen osmolarity system in patients with dry eye
title_full	Evaluation of tear osmolarity measured by I-Pen osmolarity system in patients with dry eye
title_fullStr	Evaluation of tear osmolarity measured by I-Pen osmolarity system in patients with dry eye
title_full_unstemmed	Evaluation of tear osmolarity measured by I-Pen osmolarity system in patients with dry eye
title_sort	evaluation of tear osmolarity measured by i-pen osmolarity system in patients with dry eye
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/345b512794bd4be185cdd300f187e586
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Evaluation of tear osmolarity measured by I-Pen osmolarity system in patients with dry eye

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