Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction

Individuals with autism spectrum disorder have alteration in social and novelty behaviors. Here, Bellone and colleagues show that chemogenetic inhibition of mouse dopamine neurons in the ventral tegmental area can blunt exploration towards unfamiliar conspecifics, and that these behavioral deficits...

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Autores principales:	Sebastiano Bariselli, Hanna Hörnberg, Clément Prévost-Solié, Stefano Musardo, Laetitia Hatstatt-Burklé, Peter Scheiffele, Camilla Bellone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/345bd86f687b43009338246ff0306579
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spelling	oai:doaj.org-article:345bd86f687b43009338246ff03065792021-12-02T14:40:08ZRole of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction10.1038/s41467-018-05382-32041-1723https://doaj.org/article/345bd86f687b43009338246ff03065792018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05382-3https://doaj.org/toc/2041-1723Individuals with autism spectrum disorder have alteration in social and novelty behaviors. Here, Bellone and colleagues show that chemogenetic inhibition of mouse dopamine neurons in the ventral tegmental area can blunt exploration towards unfamiliar conspecifics, and that these behavioral deficits are recapitulated in mice lacking neuroligin3 gene product.Sebastiano BariselliHanna HörnbergClément Prévost-SoliéStefano MusardoLaetitia Hatstatt-BurkléPeter ScheiffeleCamilla BelloneNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastiano Bariselli Hanna Hörnberg Clément Prévost-Solié Stefano Musardo Laetitia Hatstatt-Burklé Peter Scheiffele Camilla Bellone Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
description	Individuals with autism spectrum disorder have alteration in social and novelty behaviors. Here, Bellone and colleagues show that chemogenetic inhibition of mouse dopamine neurons in the ventral tegmental area can blunt exploration towards unfamiliar conspecifics, and that these behavioral deficits are recapitulated in mice lacking neuroligin3 gene product.
format	article
author	Sebastiano Bariselli Hanna Hörnberg Clément Prévost-Solié Stefano Musardo Laetitia Hatstatt-Burklé Peter Scheiffele Camilla Bellone
author_facet	Sebastiano Bariselli Hanna Hörnberg Clément Prévost-Solié Stefano Musardo Laetitia Hatstatt-Burklé Peter Scheiffele Camilla Bellone
author_sort	Sebastiano Bariselli
title	Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
title_short	Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
title_full	Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
title_fullStr	Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
title_full_unstemmed	Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
title_sort	role of vta dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/345bd86f687b43009338246ff0306579
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_version_	1718390407267614720

Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction

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