Leprosy morbidity and mortality in Brazil: 2008–2018

Introduction: Leprosy is an infectious disease caused by Mycobacterium leprae. This study aimed to understand the distribution and impact of Hansen's disease in different regions of Brazil and the outcome of cases in recent years. Methodology: An ecological study was conducted throughout the Br...

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Autores principales:	Camila Botelho Miguel, Patrício Barbosa da Mota, Breno Oliveira Afonso, Ferdinando Agostinho, Rodrigo Anselmo Cazzaniga, Melissa Carvalho Martins de Abreu, Carlo José Freire Oliveira, Wellington Francisco Rodrigues
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Leprosy Epidemiology Brazil Infectious and parasitic diseases RC109-216 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/345d382d5e424ba3a6aff540eab4f053
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spelling	oai:doaj.org-article:345d382d5e424ba3a6aff540eab4f0532021-11-12T04:27:53ZLeprosy morbidity and mortality in Brazil: 2008–20181413-867010.1016/j.bjid.2021.101638https://doaj.org/article/345d382d5e424ba3a6aff540eab4f0532021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1413867021001070https://doaj.org/toc/1413-8670Introduction: Leprosy is an infectious disease caused by Mycobacterium leprae. This study aimed to understand the distribution and impact of Hansen's disease in different regions of Brazil and the outcome of cases in recent years. Methodology: An ecological study was conducted throughout the Brazilian territory for 11 years (2008–2018). The mortality rates, new cases of the disease, and proportion of physical disability and cure were assessed. Data were obtained using DATASUS. GraphPad Excel and “Prisma” programs were used for tabulation and data processing. To present an accurate perspective from all regions, the data were normalized according to the population. Results: Overall, the results demonstrated a significant reduction in the number of leprosy cases in Brazil over the last decade (p < 0.05). North and Midwest regions showed higher mortality rates standardized by age (p < 0.05). The largest number of cases were found in Tocantins and Mato Grosso, inner states of Brazil (p < 0.05). The cure rates in the Southeast and South regions were negatively correlated with the mortality rate in these regions (p < 0.05). Conclusions: Actions to control the spread and unfavorable outcomes of leprosy have been effective in the last decade in most Brazilian states. On the other hand, the states of Tocantins and Mato Grosso, in the North and Midwest regions of Brazil, need to intensify the fight against the disease. Notwithstanding, measures against leprosy should continue and be intensified in regions with greater aggravations, aiming at an effective homogeneous control of the disease.Camila Botelho MiguelPatrício Barbosa da MotaBreno Oliveira AfonsoFerdinando AgostinhoRodrigo Anselmo CazzanigaMelissa Carvalho Martins de AbreuCarlo José Freire OliveiraWellington Francisco RodriguesElsevierarticleLeprosyEpidemiologyBrazilInfectious and parasitic diseasesRC109-216MicrobiologyQR1-502ENBrazilian Journal of Infectious Diseases, Vol 25, Iss 6, Pp 101638- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Leprosy Epidemiology Brazil Infectious and parasitic diseases RC109-216 Microbiology QR1-502
spellingShingle	Leprosy Epidemiology Brazil Infectious and parasitic diseases RC109-216 Microbiology QR1-502 Camila Botelho Miguel Patrício Barbosa da Mota Breno Oliveira Afonso Ferdinando Agostinho Rodrigo Anselmo Cazzaniga Melissa Carvalho Martins de Abreu Carlo José Freire Oliveira Wellington Francisco Rodrigues Leprosy morbidity and mortality in Brazil: 2008–2018
description	Introduction: Leprosy is an infectious disease caused by Mycobacterium leprae. This study aimed to understand the distribution and impact of Hansen's disease in different regions of Brazil and the outcome of cases in recent years. Methodology: An ecological study was conducted throughout the Brazilian territory for 11 years (2008–2018). The mortality rates, new cases of the disease, and proportion of physical disability and cure were assessed. Data were obtained using DATASUS. GraphPad Excel and “Prisma” programs were used for tabulation and data processing. To present an accurate perspective from all regions, the data were normalized according to the population. Results: Overall, the results demonstrated a significant reduction in the number of leprosy cases in Brazil over the last decade (p < 0.05). North and Midwest regions showed higher mortality rates standardized by age (p < 0.05). The largest number of cases were found in Tocantins and Mato Grosso, inner states of Brazil (p < 0.05). The cure rates in the Southeast and South regions were negatively correlated with the mortality rate in these regions (p < 0.05). Conclusions: Actions to control the spread and unfavorable outcomes of leprosy have been effective in the last decade in most Brazilian states. On the other hand, the states of Tocantins and Mato Grosso, in the North and Midwest regions of Brazil, need to intensify the fight against the disease. Notwithstanding, measures against leprosy should continue and be intensified in regions with greater aggravations, aiming at an effective homogeneous control of the disease.
format	article
author	Camila Botelho Miguel Patrício Barbosa da Mota Breno Oliveira Afonso Ferdinando Agostinho Rodrigo Anselmo Cazzaniga Melissa Carvalho Martins de Abreu Carlo José Freire Oliveira Wellington Francisco Rodrigues
author_facet	Camila Botelho Miguel Patrício Barbosa da Mota Breno Oliveira Afonso Ferdinando Agostinho Rodrigo Anselmo Cazzaniga Melissa Carvalho Martins de Abreu Carlo José Freire Oliveira Wellington Francisco Rodrigues
author_sort	Camila Botelho Miguel
title	Leprosy morbidity and mortality in Brazil: 2008–2018
title_short	Leprosy morbidity and mortality in Brazil: 2008–2018
title_full	Leprosy morbidity and mortality in Brazil: 2008–2018
title_fullStr	Leprosy morbidity and mortality in Brazil: 2008–2018
title_full_unstemmed	Leprosy morbidity and mortality in Brazil: 2008–2018
title_sort	leprosy morbidity and mortality in brazil: 2008–2018
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/345d382d5e424ba3a6aff540eab4f053
work_keys_str_mv	AT camilabotelhomiguel leprosymorbidityandmortalityinbrazil20082018 AT patriciobarbosadamota leprosymorbidityandmortalityinbrazil20082018 AT brenooliveiraafonso leprosymorbidityandmortalityinbrazil20082018 AT ferdinandoagostinho leprosymorbidityandmortalityinbrazil20082018 AT rodrigoanselmocazzaniga leprosymorbidityandmortalityinbrazil20082018 AT melissacarvalhomartinsdeabreu leprosymorbidityandmortalityinbrazil20082018 AT carlojosefreireoliveira leprosymorbidityandmortalityinbrazil20082018 AT wellingtonfranciscorodrigues leprosymorbidityandmortalityinbrazil20082018
_version_	1718431283422429184

Leprosy morbidity and mortality in Brazil: 2008–2018

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