Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C

Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.

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Autores principales: Nigel C. Brissett, Katerina Zabrady, Przemysław Płociński, Julie Bianchi, Małgorzata Korycka-Machała, Anna Brzostek, Jarosław Dziadek, Aidan J. Doherty
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/346123b81a9e42b09f7fa419672d0f80
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spelling oai:doaj.org-article:346123b81a9e42b09f7fa419672d0f802021-12-02T15:10:41ZMolecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C10.1038/s41467-020-18012-82041-1723https://doaj.org/article/346123b81a9e42b09f7fa419672d0f802020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18012-8https://doaj.org/toc/2041-1723Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.Nigel C. BrissettKaterina ZabradyPrzemysław PłocińskiJulie BianchiMałgorzata Korycka-MachałaAnna BrzostekJarosław DziadekAidan J. DohertyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nigel C. Brissett
Katerina Zabrady
Przemysław Płociński
Julie Bianchi
Małgorzata Korycka-Machała
Anna Brzostek
Jarosław Dziadek
Aidan J. Doherty
Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
description Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
format article
author Nigel C. Brissett
Katerina Zabrady
Przemysław Płociński
Julie Bianchi
Małgorzata Korycka-Machała
Anna Brzostek
Jarosław Dziadek
Aidan J. Doherty
author_facet Nigel C. Brissett
Katerina Zabrady
Przemysław Płociński
Julie Bianchi
Małgorzata Korycka-Machała
Anna Brzostek
Jarosław Dziadek
Aidan J. Doherty
author_sort Nigel C. Brissett
title Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
title_short Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
title_full Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
title_fullStr Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
title_full_unstemmed Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
title_sort molecular basis for dna repair synthesis on short gaps by mycobacterial primase-polymerase c
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/346123b81a9e42b09f7fa419672d0f80
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AT przemysławpłocinski molecularbasisfordnarepairsynthesisonshortgapsbymycobacterialprimasepolymerasec
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