Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C

Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.

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Auteurs principaux:	Nigel C. Brissett, Katerina Zabrady, Przemysław Płociński, Julie Bianchi, Małgorzata Korycka-Machała, Anna Brzostek, Jarosław Dziadek, Aidan J. Doherty
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/346123b81a9e42b09f7fa419672d0f80
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spelling	oai:doaj.org-article:346123b81a9e42b09f7fa419672d0f802021-12-02T15:10:41ZMolecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C10.1038/s41467-020-18012-82041-1723https://doaj.org/article/346123b81a9e42b09f7fa419672d0f802020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18012-8https://doaj.org/toc/2041-1723Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.Nigel C. BrissettKaterina ZabradyPrzemysław PłocińskiJulie BianchiMałgorzata Korycka-MachałaAnna BrzostekJarosław DziadekAidan J. DohertyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nigel C. Brissett Katerina Zabrady Przemysław Płociński Julie Bianchi Małgorzata Korycka-Machała Anna Brzostek Jarosław Dziadek Aidan J. Doherty Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
description	Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
format	article
author	Nigel C. Brissett Katerina Zabrady Przemysław Płociński Julie Bianchi Małgorzata Korycka-Machała Anna Brzostek Jarosław Dziadek Aidan J. Doherty
author_facet	Nigel C. Brissett Katerina Zabrady Przemysław Płociński Julie Bianchi Małgorzata Korycka-Machała Anna Brzostek Jarosław Dziadek Aidan J. Doherty
author_sort	Nigel C. Brissett
title	Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
title_short	Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
title_full	Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
title_fullStr	Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
title_full_unstemmed	Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
title_sort	molecular basis for dna repair synthesis on short gaps by mycobacterial primase-polymerase c
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/346123b81a9e42b09f7fa419672d0f80
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Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C

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