Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
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Nature Portfolio
2020
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oai:doaj.org-article:346123b81a9e42b09f7fa419672d0f802021-12-02T15:10:41ZMolecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C10.1038/s41467-020-18012-82041-1723https://doaj.org/article/346123b81a9e42b09f7fa419672d0f802020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18012-8https://doaj.org/toc/2041-1723Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.Nigel C. BrissettKaterina ZabradyPrzemysław PłocińskiJulie BianchiMałgorzata Korycka-MachałaAnna BrzostekJarosław DziadekAidan J. DohertyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
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Science Q Nigel C. Brissett Katerina Zabrady Przemysław Płociński Julie Bianchi Małgorzata Korycka-Machała Anna Brzostek Jarosław Dziadek Aidan J. Doherty Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C |
description |
Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism. |
format |
article |
author |
Nigel C. Brissett Katerina Zabrady Przemysław Płociński Julie Bianchi Małgorzata Korycka-Machała Anna Brzostek Jarosław Dziadek Aidan J. Doherty |
author_facet |
Nigel C. Brissett Katerina Zabrady Przemysław Płociński Julie Bianchi Małgorzata Korycka-Machała Anna Brzostek Jarosław Dziadek Aidan J. Doherty |
author_sort |
Nigel C. Brissett |
title |
Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C |
title_short |
Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C |
title_full |
Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C |
title_fullStr |
Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C |
title_full_unstemmed |
Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C |
title_sort |
molecular basis for dna repair synthesis on short gaps by mycobacterial primase-polymerase c |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/346123b81a9e42b09f7fa419672d0f80 |
work_keys_str_mv |
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