Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C

Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.

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Autores principales: Nigel C. Brissett, Katerina Zabrady, Przemysław Płociński, Julie Bianchi, Małgorzata Korycka-Machała, Anna Brzostek, Jarosław Dziadek, Aidan J. Doherty
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/346123b81a9e42b09f7fa419672d0f80
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