Peptide density targets and impedes triple negative breast cancer metastasis

The C-X-C chemokine receptor type 4 (CXCR4) pathway is a key regulator of cancer metastasis. Here, the authors present a method to block CXCR4 and thereby inhibit breast cancer metastasis by developing a liposome that presents CXCR4-binding peptides in a multivalent fashion.

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Detalles Bibliográficos
Autores principales: Daxing Liu, Peng Guo, Craig McCarthy, Biran Wang, Yu Tao, Debra Auguste
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/34668309ab9d4d19b8e724f40b74daac
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Descripción
Sumario:The C-X-C chemokine receptor type 4 (CXCR4) pathway is a key regulator of cancer metastasis. Here, the authors present a method to block CXCR4 and thereby inhibit breast cancer metastasis by developing a liposome that presents CXCR4-binding peptides in a multivalent fashion.