Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

Satellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and...

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Autores principales:	Milica Tosic, Anita Allen, Dominica Willmann, Christoph Lepper, Johnny Kim, Delphine Duteil, Roland Schüle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3468bea8b20d48ef8bf865d12864b2d3
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spelling	oai:doaj.org-article:3468bea8b20d48ef8bf865d12864b2d32021-12-02T16:49:22ZLsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells10.1038/s41467-017-02740-52041-1723https://doaj.org/article/3468bea8b20d48ef8bf865d12864b2d32018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02740-5https://doaj.org/toc/2041-1723Satellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and delays muscle regeneration in mice.Milica TosicAnita AllenDominica WillmannChristoph LepperJohnny KimDelphine DuteilRoland SchüleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Milica Tosic Anita Allen Dominica Willmann Christoph Lepper Johnny Kim Delphine Duteil Roland Schüle Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
description	Satellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and delays muscle regeneration in mice.
format	article
author	Milica Tosic Anita Allen Dominica Willmann Christoph Lepper Johnny Kim Delphine Duteil Roland Schüle
author_facet	Milica Tosic Anita Allen Dominica Willmann Christoph Lepper Johnny Kim Delphine Duteil Roland Schüle
author_sort	Milica Tosic
title	Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
title_short	Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
title_full	Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
title_fullStr	Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
title_full_unstemmed	Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
title_sort	lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3468bea8b20d48ef8bf865d12864b2d3
work_keys_str_mv	AT milicatosic lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells AT anitaallen lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells AT dominicawillmann lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells AT christophlepper lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells AT johnnykim lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells AT delphineduteil lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells AT rolandschule lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells
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Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

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