Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics
Plasmodium vivax incidence in Malaysia has declined markedly over the last decade, despite evidence of chloroquine resistance. Here, Auburn et al. compare population structure of P. vivax in Malaysia to regions with intermediate and high transmission and identify genetic regions under putative selec...
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Nature Portfolio
2018
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oai:doaj.org-article:34693c2bb3884400a72271f8a8bf03f52021-12-02T17:33:02ZGenomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics10.1038/s41467-018-04965-42041-1723https://doaj.org/article/34693c2bb3884400a72271f8a8bf03f52018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04965-4https://doaj.org/toc/2041-1723Plasmodium vivax incidence in Malaysia has declined markedly over the last decade, despite evidence of chloroquine resistance. Here, Auburn et al. compare population structure of P. vivax in Malaysia to regions with intermediate and high transmission and identify genetic regions under putative selection.Sarah AuburnErnest D. BenaventeOlivo MiottoRichard D. PearsonRoberto AmatoMatthew J. GriggBridget E. BarberTimothy WilliamIrene HandayuniJutta MarfurtHidayat TrimarsantoRintis NoviyantiKanlaya SriprawatFrancois NostenSusana CampinoTaane G. ClarkNicholas M. AnsteyDominic P. KwiatkowskiRic N. PriceNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sarah Auburn Ernest D. Benavente Olivo Miotto Richard D. Pearson Roberto Amato Matthew J. Grigg Bridget E. Barber Timothy William Irene Handayuni Jutta Marfurt Hidayat Trimarsanto Rintis Noviyanti Kanlaya Sriprawat Francois Nosten Susana Campino Taane G. Clark Nicholas M. Anstey Dominic P. Kwiatkowski Ric N. Price Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics |
| description |
Plasmodium vivax incidence in Malaysia has declined markedly over the last decade, despite evidence of chloroquine resistance. Here, Auburn et al. compare population structure of P. vivax in Malaysia to regions with intermediate and high transmission and identify genetic regions under putative selection. |
| format |
article |
| author |
Sarah Auburn Ernest D. Benavente Olivo Miotto Richard D. Pearson Roberto Amato Matthew J. Grigg Bridget E. Barber Timothy William Irene Handayuni Jutta Marfurt Hidayat Trimarsanto Rintis Noviyanti Kanlaya Sriprawat Francois Nosten Susana Campino Taane G. Clark Nicholas M. Anstey Dominic P. Kwiatkowski Ric N. Price |
| author_facet |
Sarah Auburn Ernest D. Benavente Olivo Miotto Richard D. Pearson Roberto Amato Matthew J. Grigg Bridget E. Barber Timothy William Irene Handayuni Jutta Marfurt Hidayat Trimarsanto Rintis Noviyanti Kanlaya Sriprawat Francois Nosten Susana Campino Taane G. Clark Nicholas M. Anstey Dominic P. Kwiatkowski Ric N. Price |
| author_sort |
Sarah Auburn |
| title |
Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics |
| title_short |
Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics |
| title_full |
Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics |
| title_fullStr |
Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics |
| title_full_unstemmed |
Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics |
| title_sort |
genomic analysis of a pre-elimination malaysian plasmodium vivax population reveals selective pressures and changing transmission dynamics |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/34693c2bb3884400a72271f8a8bf03f5 |
| work_keys_str_mv |
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1718380054997630976 |