Effect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophila

Abstract The effect of chrysophanic acid (CA) (2, 4, and 8 mg kg−1) on the immunity and immune-related gene profile of Catla catla against Aeromonas hydrophila is reported. In both control and treated groups fed with 2 mg kg−1 (2 CA), the phagocytosis, hemolytic, myeloperoxidase content, and superox...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ramasamy Harikrishnan, Gunapathy Devi, Chellam Balasundaram, Hien Van Doan, Sanchai Jaturasitha, Einar Ringø, Caterina Faggio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/346b7f80eeb248adb13d6272e25dcd68
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:346b7f80eeb248adb13d6272e25dcd68
record_format	dspace
spelling	oai:doaj.org-article:346b7f80eeb248adb13d6272e25dcd682021-12-02T15:23:06ZEffect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophila10.1038/s41598-020-79629-92045-2322https://doaj.org/article/346b7f80eeb248adb13d6272e25dcd682021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79629-9https://doaj.org/toc/2045-2322Abstract The effect of chrysophanic acid (CA) (2, 4, and 8 mg kg−1) on the immunity and immune-related gene profile of Catla catla against Aeromonas hydrophila is reported. In both control and treated groups fed with 2 mg kg−1 (2 CA), the phagocytosis, hemolytic, myeloperoxidase content, and superoxide anion production decreased significantly between 6th and 8th weeks, whereas when fed with 4 mg kg−1 CA (4 CA) the H2O2 production and nitric oxide synthase increased significantly between 4th and 8th week. When fed with 2 CA and 4 CA diets, the total protein, bactericidal, and antibody titer increased significantly from the 4th week onwards. When fed with 2 CA, the IL-1β and IL-10 mRNA expression of head kidney leucocytes were significant between weeks 6 and 8. The expressions of toll-like receptors significantly increased when fed with a 4 CA diet from 4th week onwards. The 4 CA group significantly increased in TNF-α, TNF receptor-associated factor 6 (NOD), which influences protein expression, after the 4th week. The mRNA transcription of MHCI, lysozyme-chicken and goose type expressions significantly increased in 4 CA group within the 4th week. In summary, the dietary administration of 4 mg kg−1 of CA (4 CA) provides better immunity and enhances the up-regulation of immune-related genes in Catla against A. hydrophila.Ramasamy HarikrishnanGunapathy DeviChellam BalasundaramHien Van DoanSanchai JaturasithaEinar RingøCaterina FaggioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ramasamy Harikrishnan Gunapathy Devi Chellam Balasundaram Hien Van Doan Sanchai Jaturasitha Einar Ringø Caterina Faggio Effect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophila
description	Abstract The effect of chrysophanic acid (CA) (2, 4, and 8 mg kg−1) on the immunity and immune-related gene profile of Catla catla against Aeromonas hydrophila is reported. In both control and treated groups fed with 2 mg kg−1 (2 CA), the phagocytosis, hemolytic, myeloperoxidase content, and superoxide anion production decreased significantly between 6th and 8th weeks, whereas when fed with 4 mg kg−1 CA (4 CA) the H2O2 production and nitric oxide synthase increased significantly between 4th and 8th week. When fed with 2 CA and 4 CA diets, the total protein, bactericidal, and antibody titer increased significantly from the 4th week onwards. When fed with 2 CA, the IL-1β and IL-10 mRNA expression of head kidney leucocytes were significant between weeks 6 and 8. The expressions of toll-like receptors significantly increased when fed with a 4 CA diet from 4th week onwards. The 4 CA group significantly increased in TNF-α, TNF receptor-associated factor 6 (NOD), which influences protein expression, after the 4th week. The mRNA transcription of MHCI, lysozyme-chicken and goose type expressions significantly increased in 4 CA group within the 4th week. In summary, the dietary administration of 4 mg kg−1 of CA (4 CA) provides better immunity and enhances the up-regulation of immune-related genes in Catla against A. hydrophila.
format	article
author	Ramasamy Harikrishnan Gunapathy Devi Chellam Balasundaram Hien Van Doan Sanchai Jaturasitha Einar Ringø Caterina Faggio
author_facet	Ramasamy Harikrishnan Gunapathy Devi Chellam Balasundaram Hien Van Doan Sanchai Jaturasitha Einar Ringø Caterina Faggio
author_sort	Ramasamy Harikrishnan
title	Effect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophila
title_short	Effect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophila
title_full	Effect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophila
title_fullStr	Effect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophila
title_full_unstemmed	Effect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophila
title_sort	effect of chrysophanic acid on immune response and immune genes transcriptomic profile in catla catla against aeromonas hydrophila
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/346b7f80eeb248adb13d6272e25dcd68
work_keys_str_mv	AT ramasamyharikrishnan effectofchrysophanicacidonimmuneresponseandimmunegenestranscriptomicprofileincatlacatlaagainstaeromonashydrophila AT gunapathydevi effectofchrysophanicacidonimmuneresponseandimmunegenestranscriptomicprofileincatlacatlaagainstaeromonashydrophila AT chellambalasundaram effectofchrysophanicacidonimmuneresponseandimmunegenestranscriptomicprofileincatlacatlaagainstaeromonashydrophila AT hienvandoan effectofchrysophanicacidonimmuneresponseandimmunegenestranscriptomicprofileincatlacatlaagainstaeromonashydrophila AT sanchaijaturasitha effectofchrysophanicacidonimmuneresponseandimmunegenestranscriptomicprofileincatlacatlaagainstaeromonashydrophila AT einarringø effectofchrysophanicacidonimmuneresponseandimmunegenestranscriptomicprofileincatlacatlaagainstaeromonashydrophila AT caterinafaggio effectofchrysophanicacidonimmuneresponseandimmunegenestranscriptomicprofileincatlacatlaagainstaeromonashydrophila
_version_	1718387315934494720

Effect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophila

Ejemplares similares