Routinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study

Abstract The objective was to evaluate the sequentially updated predictive capacity for preeclampsia during pregnancy, using multivariable longitudinal models including data from antenatal care. This population-based cohort study in the Stockholm-Gotland Counties, Sweden, included 58,899 pregnancies...

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Autores principales:	Anna Sandström, Jonathan M. Snowden, Matteo Bottai, Olof Stephansson, Anna-Karin Wikström
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/346b9fcaece842748a5b843f0fcd4e3a
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spelling	oai:doaj.org-article:346b9fcaece842748a5b843f0fcd4e3a2021-12-02T19:12:27ZRoutinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study10.1038/s41598-021-97465-32045-2322https://doaj.org/article/346b9fcaece842748a5b843f0fcd4e3a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97465-3https://doaj.org/toc/2045-2322Abstract The objective was to evaluate the sequentially updated predictive capacity for preeclampsia during pregnancy, using multivariable longitudinal models including data from antenatal care. This population-based cohort study in the Stockholm-Gotland Counties, Sweden, included 58,899 pregnancies of nulliparous women 2008–2013. Prospectively collected data from each antenatal care visit was used, including maternal characteristics, reproductive and medical history, and repeated measurements of blood pressure, weight, symphysis-fundal height, proteinuria, hemoglobin and blood glucose levels. We used a shared-effects joint longitudinal model including all available information up until a given gestational length (week 24, 28, 32, 34 and 36), to update preeclampsia prediction sequentially. Outcome measures were prediction of preeclampsia, preeclampsia with delivery < 37, and preeclampsia with delivery ≥ 37 weeks’ gestation. The area under the curve (AUC) increased with gestational length. AUC for preeclampsia with delivery < 37 weeks’ gestation was 0.73 (95% CI 0.68–0.79) at week 24, and increased to 0.87 (95% CI 0.84–0.90) in week 34. For preeclampsia with delivery ≥ 37 weeks’ gestation, the AUC in week 24 was 0.65 (95% CI 0.63–0.68), but increased to 0.79 (95% CI 0.78–0.80) in week 36. The addition of routinely collected clinical measurements throughout pregnancy improve preeclampsia prediction and may be useful to individualize antenatal care.Anna SandströmJonathan M. SnowdenMatteo BottaiOlof StephanssonAnna-Karin WikströmNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Sandström Jonathan M. Snowden Matteo Bottai Olof Stephansson Anna-Karin Wikström Routinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study
description	Abstract The objective was to evaluate the sequentially updated predictive capacity for preeclampsia during pregnancy, using multivariable longitudinal models including data from antenatal care. This population-based cohort study in the Stockholm-Gotland Counties, Sweden, included 58,899 pregnancies of nulliparous women 2008–2013. Prospectively collected data from each antenatal care visit was used, including maternal characteristics, reproductive and medical history, and repeated measurements of blood pressure, weight, symphysis-fundal height, proteinuria, hemoglobin and blood glucose levels. We used a shared-effects joint longitudinal model including all available information up until a given gestational length (week 24, 28, 32, 34 and 36), to update preeclampsia prediction sequentially. Outcome measures were prediction of preeclampsia, preeclampsia with delivery < 37, and preeclampsia with delivery ≥ 37 weeks’ gestation. The area under the curve (AUC) increased with gestational length. AUC for preeclampsia with delivery < 37 weeks’ gestation was 0.73 (95% CI 0.68–0.79) at week 24, and increased to 0.87 (95% CI 0.84–0.90) in week 34. For preeclampsia with delivery ≥ 37 weeks’ gestation, the AUC in week 24 was 0.65 (95% CI 0.63–0.68), but increased to 0.79 (95% CI 0.78–0.80) in week 36. The addition of routinely collected clinical measurements throughout pregnancy improve preeclampsia prediction and may be useful to individualize antenatal care.
format	article
author	Anna Sandström Jonathan M. Snowden Matteo Bottai Olof Stephansson Anna-Karin Wikström
author_facet	Anna Sandström Jonathan M. Snowden Matteo Bottai Olof Stephansson Anna-Karin Wikström
author_sort	Anna Sandström
title	Routinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study
title_short	Routinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study
title_full	Routinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study
title_fullStr	Routinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study
title_full_unstemmed	Routinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study
title_sort	routinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/346b9fcaece842748a5b843f0fcd4e3a
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Routinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study

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