Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic <italic toggle="yes">Escherichia coli</italic>

ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) is a major cause of foodborne gastrointestinal illness. EHEC uses a specialized type III secretion system (T3SS) to form attaching and effacing lesions in the colonic epithelium and outcompete commensal gut microbiota to cause disease. A recent repo...

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Autores principales:	Lauren D. Palmer, Eric P. Skaar
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	EHEC commensal microbiota protease virulence Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/346e6c81de8f4eac9abea04b59e25ef8
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spelling	oai:doaj.org-article:346e6c81de8f4eac9abea04b59e25ef82021-11-15T15:55:14ZCuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic <italic toggle="yes">Escherichia coli</italic>10.1128/mBio.00115-192150-7511https://doaj.org/article/346e6c81de8f4eac9abea04b59e25ef82019-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00115-19https://doaj.org/toc/2150-7511ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) is a major cause of foodborne gastrointestinal illness. EHEC uses a specialized type III secretion system (T3SS) to form attaching and effacing lesions in the colonic epithelium and outcompete commensal gut microbiota to cause disease. A recent report in mBio (E. A. Cameron, M. M. Curtis, A. Kumar, G. M. Dunny, et al., mBio 9:e02204-18, 2018, https://doi.org/10.1128/mBio.02204-18) describes a new role for gut commensals in potentiating disease caused by EHEC. Proteases produced by EHEC and the prevalent human commensal Bacteroides thetaiotaomicron cleave proteins in the EHEC T3SS translocon that modulate T3SS function. B. thetaiotaomicron protease activity promotes translocation of bacterial effectors required for lesion formation. These results describe a new role for the microbiota in gastrointestinal disease that could uncover future treatments to prevent the spread of gastroenteritis.Lauren D. PalmerEric P. SkaarAmerican Society for MicrobiologyarticleEHECcommensalmicrobiotaproteasevirulenceMicrobiologyQR1-502ENmBio, Vol 10, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	EHEC commensal microbiota protease virulence Microbiology QR1-502
spellingShingle	EHEC commensal microbiota protease virulence Microbiology QR1-502 Lauren D. Palmer Eric P. Skaar Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic <italic toggle="yes">Escherichia coli</italic>
description	ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) is a major cause of foodborne gastrointestinal illness. EHEC uses a specialized type III secretion system (T3SS) to form attaching and effacing lesions in the colonic epithelium and outcompete commensal gut microbiota to cause disease. A recent report in mBio (E. A. Cameron, M. M. Curtis, A. Kumar, G. M. Dunny, et al., mBio 9:e02204-18, 2018, https://doi.org/10.1128/mBio.02204-18) describes a new role for gut commensals in potentiating disease caused by EHEC. Proteases produced by EHEC and the prevalent human commensal Bacteroides thetaiotaomicron cleave proteins in the EHEC T3SS translocon that modulate T3SS function. B. thetaiotaomicron protease activity promotes translocation of bacterial effectors required for lesion formation. These results describe a new role for the microbiota in gastrointestinal disease that could uncover future treatments to prevent the spread of gastroenteritis.
format	article
author	Lauren D. Palmer Eric P. Skaar
author_facet	Lauren D. Palmer Eric P. Skaar
author_sort	Lauren D. Palmer
title	Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic <italic toggle="yes">Escherichia coli</italic>
title_short	Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic <italic toggle="yes">Escherichia coli</italic>
title_full	Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic <italic toggle="yes">Escherichia coli</italic>
title_fullStr	Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic <italic toggle="yes">Escherichia coli</italic>
title_full_unstemmed	Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic <italic toggle="yes">Escherichia coli</italic>
title_sort	cuts both ways: proteases modulate virulence of enterohemorrhagic <italic toggle="yes">escherichia coli</italic>
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/346e6c81de8f4eac9abea04b59e25ef8
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Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic <italic toggle="yes">Escherichia coli</italic>

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