The strong in vivo anti-tumor effect of the UIC2 monoclonal antibody is the combined result of Pgp inhibition and antibody dependent cell-mediated cytotoxicity.

The strong in vivo anti-tumor effect of the UIC2 monoclonal antibody is the combined result of Pgp inhibition and antibody dependent cell-mediated cytotoxicity.

P-glycoprotein (Pgp) extrudes a large variety of chemotherapeutic drugs from the cells, causing multidrug resistance (MDR). The UIC2 monoclonal antibody recognizes human Pgp and inhibits its drug transport activity. However, this inhibition is partial, since UIC2 binds only to 10-40% of cell surface...

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Autores principales: Gábor Szalóki, Zoárd T Krasznai, Ágnes Tóth, Laura Vízkeleti, Attila G Szöllősi, György Trencsényi, Imre Lajtos, István Juhász, Zoltán Krasznai, Teréz Márián, Margit Balázs, Gábor Szabó, Katalin Goda
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/3470007aea544df980b1d9799a7c5211
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