Early life exposures associated with risk of small intestinal neuroendocrine tumors.

Small intestinal neuroendocrine tumors (SINT) are rare with incidence increasing over the past 40 years. The purpose of this work is to examine the role of environmental exposures in the rise of SINT incidence using the Utah Population Database, a resource of linked records including life events, ca...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	James VanDerslice, Marissa C Taddie, Karen Curtin, Caroline Miller, Zhe Yu, Rachael Hemmert, Lisa A Cannon-Albright, Deborah W Neklason
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34715f0b4c47486b87afbb1ab7213028
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:34715f0b4c47486b87afbb1ab7213028
record_format	dspace
spelling	oai:doaj.org-article:34715f0b4c47486b87afbb1ab72130282021-12-02T20:15:51ZEarly life exposures associated with risk of small intestinal neuroendocrine tumors.1932-620310.1371/journal.pone.0231991https://doaj.org/article/34715f0b4c47486b87afbb1ab72130282020-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0231991https://doaj.org/toc/1932-6203Small intestinal neuroendocrine tumors (SINT) are rare with incidence increasing over the past 40 years. The purpose of this work is to examine the role of environmental exposures in the rise of SINT incidence using the Utah Population Database, a resource of linked records including life events, cancer diagnoses and residential histories. SINT cases born in Utah were identified through the Utah Cancer Registry with: diagnosis years of 1948 to 2014 and age at diagnosis of 23 to 88 years. Controls were matched to cases 10:1 based on sex, birth year and residence time in Utah. Cases and controls were geocoded to their birth locale. An isotonic spatial scan statistic was used to test for the occurrence and location(s) of SINT clusters. Potential environmental exposures and economic conditions in the birth locales at the time of the birth (1883-1982) were generated using historical references. Conditional logistic regression was used to estimate odd ratios. We report a spatial cluster central to historic coal mining communities, associated with a 2.86 relative risk (p = 0.016) of SINT. Aspatial analyses of industry and mining exposures further suggest elevated risk for early life exposure near areas involved in the construction industry (OR 1.98 p = 0.024). Other exposures approached significance including coal, uranium and hard rock mining during the earliest period (1883-1929) when safety from exposures was not considered. We do observe a lower risk (OR 0.58 p = 0.033) associated with individuals born in rural areas in the most recent period (1945-1982). Environmental exposures early in life, especially those from industries such as mining, may confer an elevated risk of SINT.James VanDersliceMarissa C TaddieKaren CurtinCaroline MillerZhe YuRachael HemmertLisa A Cannon-AlbrightDeborah W NeklasonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 15, Iss 4, p e0231991 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q James VanDerslice Marissa C Taddie Karen Curtin Caroline Miller Zhe Yu Rachael Hemmert Lisa A Cannon-Albright Deborah W Neklason Early life exposures associated with risk of small intestinal neuroendocrine tumors.
description	Small intestinal neuroendocrine tumors (SINT) are rare with incidence increasing over the past 40 years. The purpose of this work is to examine the role of environmental exposures in the rise of SINT incidence using the Utah Population Database, a resource of linked records including life events, cancer diagnoses and residential histories. SINT cases born in Utah were identified through the Utah Cancer Registry with: diagnosis years of 1948 to 2014 and age at diagnosis of 23 to 88 years. Controls were matched to cases 10:1 based on sex, birth year and residence time in Utah. Cases and controls were geocoded to their birth locale. An isotonic spatial scan statistic was used to test for the occurrence and location(s) of SINT clusters. Potential environmental exposures and economic conditions in the birth locales at the time of the birth (1883-1982) were generated using historical references. Conditional logistic regression was used to estimate odd ratios. We report a spatial cluster central to historic coal mining communities, associated with a 2.86 relative risk (p = 0.016) of SINT. Aspatial analyses of industry and mining exposures further suggest elevated risk for early life exposure near areas involved in the construction industry (OR 1.98 p = 0.024). Other exposures approached significance including coal, uranium and hard rock mining during the earliest period (1883-1929) when safety from exposures was not considered. We do observe a lower risk (OR 0.58 p = 0.033) associated with individuals born in rural areas in the most recent period (1945-1982). Environmental exposures early in life, especially those from industries such as mining, may confer an elevated risk of SINT.
format	article
author	James VanDerslice Marissa C Taddie Karen Curtin Caroline Miller Zhe Yu Rachael Hemmert Lisa A Cannon-Albright Deborah W Neklason
author_facet	James VanDerslice Marissa C Taddie Karen Curtin Caroline Miller Zhe Yu Rachael Hemmert Lisa A Cannon-Albright Deborah W Neklason
author_sort	James VanDerslice
title	Early life exposures associated with risk of small intestinal neuroendocrine tumors.
title_short	Early life exposures associated with risk of small intestinal neuroendocrine tumors.
title_full	Early life exposures associated with risk of small intestinal neuroendocrine tumors.
title_fullStr	Early life exposures associated with risk of small intestinal neuroendocrine tumors.
title_full_unstemmed	Early life exposures associated with risk of small intestinal neuroendocrine tumors.
title_sort	early life exposures associated with risk of small intestinal neuroendocrine tumors.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/34715f0b4c47486b87afbb1ab7213028
work_keys_str_mv	AT jamesvanderslice earlylifeexposuresassociatedwithriskofsmallintestinalneuroendocrinetumors AT marissactaddie earlylifeexposuresassociatedwithriskofsmallintestinalneuroendocrinetumors AT karencurtin earlylifeexposuresassociatedwithriskofsmallintestinalneuroendocrinetumors AT carolinemiller earlylifeexposuresassociatedwithriskofsmallintestinalneuroendocrinetumors AT zheyu earlylifeexposuresassociatedwithriskofsmallintestinalneuroendocrinetumors AT rachaelhemmert earlylifeexposuresassociatedwithriskofsmallintestinalneuroendocrinetumors AT lisaacannonalbright earlylifeexposuresassociatedwithriskofsmallintestinalneuroendocrinetumors AT deborahwneklason earlylifeexposuresassociatedwithriskofsmallintestinalneuroendocrinetumors
_version_	1718374517914468352

Early life exposures associated with risk of small intestinal neuroendocrine tumors.

Ejemplares similares