Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

Epithelial cells that line the gut secrete complex glycoproteins that form a mucus layer to protect the gut wall from enteric pathogens. Here, the authors provide a comprehensive characterisation of endo-acting glycoside hydrolases expressed by mucin-degrading members of the microbiome that are able...

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Autores principales:	Lucy I. Crouch, Marcelo V. Liberato, Paulina A. Urbanowicz, Arnaud Baslé, Christopher A. Lamb, Christopher J. Stewart, Katie Cooke, Mary Doona, Stephanie Needham, Richard R. Brady, Janet E. Berrington, Katarina Madunic, Manfred Wuhrer, Peter Chater, Jeffery P. Pearson, Robert Glowacki, Eric C. Martens, Fuming Zhang, Robert J. Linhardt, Daniel I. R. Spencer, David N. Bolam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/34729e0035e248979eeaf2cddb4c661b
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spelling	oai:doaj.org-article:34729e0035e248979eeaf2cddb4c661b2021-12-02T16:28:07ZProminent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown10.1038/s41467-020-17847-52041-1723https://doaj.org/article/34729e0035e248979eeaf2cddb4c661b2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17847-5https://doaj.org/toc/2041-1723Epithelial cells that line the gut secrete complex glycoproteins that form a mucus layer to protect the gut wall from enteric pathogens. Here, the authors provide a comprehensive characterisation of endo-acting glycoside hydrolases expressed by mucin-degrading members of the microbiome that are able to cleave the O-glycan chains of a range of different animal and human mucins.Lucy I. CrouchMarcelo V. LiberatoPaulina A. UrbanowiczArnaud BasléChristopher A. LambChristopher J. StewartKatie CookeMary DoonaStephanie NeedhamRichard R. BradyJanet E. BerringtonKatarina MadunicManfred WuhrerPeter ChaterJeffery P. PearsonRobert GlowackiEric C. MartensFuming ZhangRobert J. LinhardtDaniel I. R. SpencerDavid N. BolamNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucy I. Crouch Marcelo V. Liberato Paulina A. Urbanowicz Arnaud Baslé Christopher A. Lamb Christopher J. Stewart Katie Cooke Mary Doona Stephanie Needham Richard R. Brady Janet E. Berrington Katarina Madunic Manfred Wuhrer Peter Chater Jeffery P. Pearson Robert Glowacki Eric C. Martens Fuming Zhang Robert J. Linhardt Daniel I. R. Spencer David N. Bolam Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
description	Epithelial cells that line the gut secrete complex glycoproteins that form a mucus layer to protect the gut wall from enteric pathogens. Here, the authors provide a comprehensive characterisation of endo-acting glycoside hydrolases expressed by mucin-degrading members of the microbiome that are able to cleave the O-glycan chains of a range of different animal and human mucins.
format	article
author	Lucy I. Crouch Marcelo V. Liberato Paulina A. Urbanowicz Arnaud Baslé Christopher A. Lamb Christopher J. Stewart Katie Cooke Mary Doona Stephanie Needham Richard R. Brady Janet E. Berrington Katarina Madunic Manfred Wuhrer Peter Chater Jeffery P. Pearson Robert Glowacki Eric C. Martens Fuming Zhang Robert J. Linhardt Daniel I. R. Spencer David N. Bolam
author_facet	Lucy I. Crouch Marcelo V. Liberato Paulina A. Urbanowicz Arnaud Baslé Christopher A. Lamb Christopher J. Stewart Katie Cooke Mary Doona Stephanie Needham Richard R. Brady Janet E. Berrington Katarina Madunic Manfred Wuhrer Peter Chater Jeffery P. Pearson Robert Glowacki Eric C. Martens Fuming Zhang Robert J. Linhardt Daniel I. R. Spencer David N. Bolam
author_sort	Lucy I. Crouch
title	Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
title_short	Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
title_full	Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
title_fullStr	Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
title_full_unstemmed	Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
title_sort	prominent members of the human gut microbiota express endo-acting o-glycanases to initiate mucin breakdown
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/34729e0035e248979eeaf2cddb4c661b
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Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

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