2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions

UV-induced photodamage that likely occurred during the prebiotic synthesis of DNA and RNA is still an untackled issue for their origin on early Earth. Here, the authors show that substitution of 2,6-diaminopurine for adenine enables repair of cyclobutane pyrimidine dimers with high yields, and demon...

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Autores principales:	Rafał Szabla, Magdalena Zdrowowicz, Paulina Spisz, Nicholas J. Green, Petr Stadlbauer, Holger Kruse, Jiří Šponer, Janusz Rak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/347696f7b33c4b0fa6bc7bc725ea0853
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spelling	oai:doaj.org-article:347696f7b33c4b0fa6bc7bc725ea08532021-12-02T14:58:51Z2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions10.1038/s41467-021-23300-y2041-1723https://doaj.org/article/347696f7b33c4b0fa6bc7bc725ea08532021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23300-yhttps://doaj.org/toc/2041-1723UV-induced photodamage that likely occurred during the prebiotic synthesis of DNA and RNA is still an untackled issue for their origin on early Earth. Here, the authors show that substitution of 2,6-diaminopurine for adenine enables repair of cyclobutane pyrimidine dimers with high yields, and demonstrate that both 2,6-diaminopurine and adenine nucleosides can be formed under the same prebiotic conditions.Rafał SzablaMagdalena ZdrowowiczPaulina SpiszNicholas J. GreenPetr StadlbauerHolger KruseJiří ŠponerJanusz RakNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rafał Szabla Magdalena Zdrowowicz Paulina Spisz Nicholas J. Green Petr Stadlbauer Holger Kruse Jiří Šponer Janusz Rak 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions
description	UV-induced photodamage that likely occurred during the prebiotic synthesis of DNA and RNA is still an untackled issue for their origin on early Earth. Here, the authors show that substitution of 2,6-diaminopurine for adenine enables repair of cyclobutane pyrimidine dimers with high yields, and demonstrate that both 2,6-diaminopurine and adenine nucleosides can be formed under the same prebiotic conditions.
format	article
author	Rafał Szabla Magdalena Zdrowowicz Paulina Spisz Nicholas J. Green Petr Stadlbauer Holger Kruse Jiří Šponer Janusz Rak
author_facet	Rafał Szabla Magdalena Zdrowowicz Paulina Spisz Nicholas J. Green Petr Stadlbauer Holger Kruse Jiří Šponer Janusz Rak
author_sort	Rafał Szabla
title	2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions
title_short	2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions
title_full	2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions
title_fullStr	2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions
title_full_unstemmed	2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions
title_sort	2,6-diaminopurine promotes repair of dna lesions under prebiotic conditions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/347696f7b33c4b0fa6bc7bc725ea0853
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2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions

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