A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

Galectin-3 is a sugar-binding protein that can inhibit antitumour cytotoxic immunity. Here the authors show that Galectin-3 expressed by tumour cells inhibits LFA-1 on cytotoxic lymphocytes, impairing immunological synapse formation, IFNg secretion, and target cell killing.

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Autores principales: Anne-Elisabeth Petit, Nathalie Demotte, Benoît Scheid, Claude Wildmann, René Bigirimana, Monica Gordon-Alonso, Javier Carrasco, Salvatore Valitutti, Danièle Godelaine, Pierre van der Bruggen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/3477da4108d44f4daa43367177312336
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spelling oai:doaj.org-article:3477da4108d44f4daa433671773123362021-12-02T16:50:55ZA major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion10.1038/ncomms122422041-1723https://doaj.org/article/3477da4108d44f4daa433671773123362016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12242https://doaj.org/toc/2041-1723Galectin-3 is a sugar-binding protein that can inhibit antitumour cytotoxic immunity. Here the authors show that Galectin-3 expressed by tumour cells inhibits LFA-1 on cytotoxic lymphocytes, impairing immunological synapse formation, IFNg secretion, and target cell killing.Anne-Elisabeth PetitNathalie DemotteBenoît ScheidClaude WildmannRené BigirimanaMonica Gordon-AlonsoJavier CarrascoSalvatore ValituttiDanièle GodelainePierre van der BruggenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anne-Elisabeth Petit
Nathalie Demotte
Benoît Scheid
Claude Wildmann
René Bigirimana
Monica Gordon-Alonso
Javier Carrasco
Salvatore Valitutti
Danièle Godelaine
Pierre van der Bruggen
A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion
description Galectin-3 is a sugar-binding protein that can inhibit antitumour cytotoxic immunity. Here the authors show that Galectin-3 expressed by tumour cells inhibits LFA-1 on cytotoxic lymphocytes, impairing immunological synapse formation, IFNg secretion, and target cell killing.
format article
author Anne-Elisabeth Petit
Nathalie Demotte
Benoît Scheid
Claude Wildmann
René Bigirimana
Monica Gordon-Alonso
Javier Carrasco
Salvatore Valitutti
Danièle Godelaine
Pierre van der Bruggen
author_facet Anne-Elisabeth Petit
Nathalie Demotte
Benoît Scheid
Claude Wildmann
René Bigirimana
Monica Gordon-Alonso
Javier Carrasco
Salvatore Valitutti
Danièle Godelaine
Pierre van der Bruggen
author_sort Anne-Elisabeth Petit
title A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion
title_short A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion
title_full A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion
title_fullStr A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion
title_full_unstemmed A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion
title_sort major secretory defect of tumour-infiltrating t lymphocytes due to galectin impairing lfa-1-mediated synapse completion
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/3477da4108d44f4daa43367177312336
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