Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

Mutations in the human POLE gene are associated with tumours with high mutational loads. Here the authors provide a structural rationale for the mutagenic activity of the cancer-associated DNA polymerase ε P286R variant.

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Autores principales:	Vimal Parkash, Yashraj Kulkarni, Josy ter Beek, Polina V. Shcherbakova, Shina Caroline Lynn Kamerlin, Erik Johansson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/347e31414f014ab19733e8e7a0a88110
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spelling	oai:doaj.org-article:347e31414f014ab19733e8e7a0a881102021-12-02T17:02:19ZStructural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε10.1038/s41467-018-08114-92041-1723https://doaj.org/article/347e31414f014ab19733e8e7a0a881102019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08114-9https://doaj.org/toc/2041-1723Mutations in the human POLE gene are associated with tumours with high mutational loads. Here the authors provide a structural rationale for the mutagenic activity of the cancer-associated DNA polymerase ε P286R variant.Vimal ParkashYashraj KulkarniJosy ter BeekPolina V. ShcherbakovaShina Caroline Lynn KamerlinErik JohanssonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vimal Parkash Yashraj Kulkarni Josy ter Beek Polina V. Shcherbakova Shina Caroline Lynn Kamerlin Erik Johansson Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε
description	Mutations in the human POLE gene are associated with tumours with high mutational loads. Here the authors provide a structural rationale for the mutagenic activity of the cancer-associated DNA polymerase ε P286R variant.
format	article
author	Vimal Parkash Yashraj Kulkarni Josy ter Beek Polina V. Shcherbakova Shina Caroline Lynn Kamerlin Erik Johansson
author_facet	Vimal Parkash Yashraj Kulkarni Josy ter Beek Polina V. Shcherbakova Shina Caroline Lynn Kamerlin Erik Johansson
author_sort	Vimal Parkash
title	Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε
title_short	Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε
title_full	Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε
title_fullStr	Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε
title_full_unstemmed	Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε
title_sort	structural consequence of the most frequently recurring cancer-associated substitution in dna polymerase ε
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/347e31414f014ab19733e8e7a0a88110
work_keys_str_mv	AT vimalparkash structuralconsequenceofthemostfrequentlyrecurringcancerassociatedsubstitutionindnapolymerasee AT yashrajkulkarni structuralconsequenceofthemostfrequentlyrecurringcancerassociatedsubstitutionindnapolymerasee AT josyterbeek structuralconsequenceofthemostfrequentlyrecurringcancerassociatedsubstitutionindnapolymerasee AT polinavshcherbakova structuralconsequenceofthemostfrequentlyrecurringcancerassociatedsubstitutionindnapolymerasee AT shinacarolinelynnkamerlin structuralconsequenceofthemostfrequentlyrecurringcancerassociatedsubstitutionindnapolymerasee AT erikjohansson structuralconsequenceofthemostfrequentlyrecurringcancerassociatedsubstitutionindnapolymerasee
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Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

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