Kisspeptin: A Central Regulator of Reproduction in Mammals

The discovery of the role of kisspeptin neurons in the regulation of mammalian reproduction in 2003 was one of the biggest breakthroughs in reproductive endocrinology within the last few decades. Research during the past two decades since the discovery of kisspeptin has been unveiling the mechanism...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nahoko Ieda, Ahmed SA Hassaneen, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura
Formato:	article
Lenguaje:	EN
Publicado:	South Valley University 2019
Materias:	anteroventral periventricular nucleus arcuate nucleus fertility gonadotropins pre-optic area Agriculture S Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/3480d7f96f0041d8b7d797a6900c8a26
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3480d7f96f0041d8b7d797a6900c8a26
record_format	dspace
spelling	oai:doaj.org-article:3480d7f96f0041d8b7d797a6900c8a262021-12-02T15:38:02Z Kisspeptin: A Central Regulator of Reproduction in Mammals10.21608/svu.2019.16569.10272535-18262535-1877https://doaj.org/article/3480d7f96f0041d8b7d797a6900c8a262019-11-01T00:00:00Zhttps://svu.journals.ekb.eg/article_58205.htmlhttps://doaj.org/toc/2535-1826https://doaj.org/toc/2535-1877The discovery of the role of kisspeptin neurons in the regulation of mammalian reproduction in 2003 was one of the biggest breakthroughs in reproductive endocrinology within the last few decades. Research during the past two decades since the discovery of kisspeptin has been unveiling the mechanism of how the hypothalamic kisspeptin neurons control reproductive functions through regulation of gonadotropin-releasing hormone (GnRH) secretion. This article aims to overview kisspeptin research, including the most recent studies from ours and other research groups, and to discuss the possibility of new strategies to control reproductive functions in farm animals. In the first section, we introduce the critical role of kisspeptin neurons in puberty onset and reproductive functions in mammals, including the regulation of two modes of GnRH/gonadotropin secretion, namely pulsatile and surge modes. The next section focuses more on the mechanism of how the kisspeptin neurons in the arcuate nucleus in the hypothalamus precisely controls GnRH pulse using other two neuropeptides, neurokinin B and dynorphin A. The article also discusses the mechanism suppressing reproductive function during lactation and other stress conditions through inhibition of kisspeptin neurons and consequent GnRH/gonadotropin secretion, to provide insights on the possibility of new strategies to control reproductive performance in domestic farm animals.Nahoko Ieda Ahmed SA HassaneenNaoko InoueYoshihisa Uenoyama Hiroko TsukamuraSouth Valley Universityarticleanteroventral periventricular nucleusarcuate nucleusfertilitygonadotropinspre-optic areaAgricultureSVeterinary medicineSF600-1100ENSVU-International Journal of Veterinary Sciences, Vol 3, Iss 1, Pp 10-26 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	anteroventral periventricular nucleus arcuate nucleus fertility gonadotropins pre-optic area Agriculture S Veterinary medicine SF600-1100
spellingShingle	anteroventral periventricular nucleus arcuate nucleus fertility gonadotropins pre-optic area Agriculture S Veterinary medicine SF600-1100 Nahoko Ieda Ahmed SA Hassaneen Naoko Inoue Yoshihisa Uenoyama Hiroko Tsukamura Kisspeptin: A Central Regulator of Reproduction in Mammals
description	The discovery of the role of kisspeptin neurons in the regulation of mammalian reproduction in 2003 was one of the biggest breakthroughs in reproductive endocrinology within the last few decades. Research during the past two decades since the discovery of kisspeptin has been unveiling the mechanism of how the hypothalamic kisspeptin neurons control reproductive functions through regulation of gonadotropin-releasing hormone (GnRH) secretion. This article aims to overview kisspeptin research, including the most recent studies from ours and other research groups, and to discuss the possibility of new strategies to control reproductive functions in farm animals. In the first section, we introduce the critical role of kisspeptin neurons in puberty onset and reproductive functions in mammals, including the regulation of two modes of GnRH/gonadotropin secretion, namely pulsatile and surge modes. The next section focuses more on the mechanism of how the kisspeptin neurons in the arcuate nucleus in the hypothalamus precisely controls GnRH pulse using other two neuropeptides, neurokinin B and dynorphin A. The article also discusses the mechanism suppressing reproductive function during lactation and other stress conditions through inhibition of kisspeptin neurons and consequent GnRH/gonadotropin secretion, to provide insights on the possibility of new strategies to control reproductive performance in domestic farm animals.
format	article
author	Nahoko Ieda Ahmed SA Hassaneen Naoko Inoue Yoshihisa Uenoyama Hiroko Tsukamura
author_facet	Nahoko Ieda Ahmed SA Hassaneen Naoko Inoue Yoshihisa Uenoyama Hiroko Tsukamura
author_sort	Nahoko Ieda
title	Kisspeptin: A Central Regulator of Reproduction in Mammals
title_short	Kisspeptin: A Central Regulator of Reproduction in Mammals
title_full	Kisspeptin: A Central Regulator of Reproduction in Mammals
title_fullStr	Kisspeptin: A Central Regulator of Reproduction in Mammals
title_full_unstemmed	Kisspeptin: A Central Regulator of Reproduction in Mammals
title_sort	kisspeptin: a central regulator of reproduction in mammals
publisher	South Valley University
publishDate	2019
url	https://doaj.org/article/3480d7f96f0041d8b7d797a6900c8a26
work_keys_str_mv	AT nahokoieda kisspeptinacentralregulatorofreproductioninmammals AT ahmedsahassaneen kisspeptinacentralregulatorofreproductioninmammals AT naokoinoue kisspeptinacentralregulatorofreproductioninmammals AT yoshihisauenoyama kisspeptinacentralregulatorofreproductioninmammals AT hirokotsukamura kisspeptinacentralregulatorofreproductioninmammals
_version_	1718386164694515712

Kisspeptin: A Central Regulator of Reproduction in Mammals

Ejemplares similares