Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation

Whether chronic inflammation contributes to metabolic disease through the dysregulation of circadian systems remains incompletely understood in humans. Here the authors show that circadian clock function is perturbed in adipose tissue from individuals with obesity, and that inhibition of NFkB improv...

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Autores principales:	Eleonore Maury, Benoit Navez, Sonia M. Brichard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/34819e9b88974b4093d7a21b2a8bb43e
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spelling	oai:doaj.org-article:34819e9b88974b4093d7a21b2a8bb43e2021-12-02T18:28:38ZCircadian clock dysfunction in human omental fat links obesity to metabolic inflammation10.1038/s41467-021-22571-92041-1723https://doaj.org/article/34819e9b88974b4093d7a21b2a8bb43e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22571-9https://doaj.org/toc/2041-1723Whether chronic inflammation contributes to metabolic disease through the dysregulation of circadian systems remains incompletely understood in humans. Here the authors show that circadian clock function is perturbed in adipose tissue from individuals with obesity, and that inhibition of NFkB improves clock function.Eleonore MauryBenoit NavezSonia M. BrichardNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eleonore Maury Benoit Navez Sonia M. Brichard Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation
description	Whether chronic inflammation contributes to metabolic disease through the dysregulation of circadian systems remains incompletely understood in humans. Here the authors show that circadian clock function is perturbed in adipose tissue from individuals with obesity, and that inhibition of NFkB improves clock function.
format	article
author	Eleonore Maury Benoit Navez Sonia M. Brichard
author_facet	Eleonore Maury Benoit Navez Sonia M. Brichard
author_sort	Eleonore Maury
title	Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation
title_short	Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation
title_full	Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation
title_fullStr	Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation
title_full_unstemmed	Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation
title_sort	circadian clock dysfunction in human omental fat links obesity to metabolic inflammation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/34819e9b88974b4093d7a21b2a8bb43e
work_keys_str_mv	AT eleonoremaury circadianclockdysfunctioninhumanomentalfatlinksobesitytometabolicinflammation AT benoitnavez circadianclockdysfunctioninhumanomentalfatlinksobesitytometabolicinflammation AT soniambrichard circadianclockdysfunctioninhumanomentalfatlinksobesitytometabolicinflammation
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Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation

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