Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation

Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation

The XPF-ERCC1 heterodimer is an endonuclease involved in nucleotide excision (NER) and interstrand crosslink (ICL) repair in mammalian cells. Here, the authors provide insights into its regulation by revealing that TIP60 regulates XPF-ERCC1 complex assembly and activation.

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Autores principales: Jiajia Wang, Hanqing He, Binbin Chen, Guixing Jiang, Liping Cao, Haiping Jiang, Guofei Zhang, Jianxiang Chen, Jun Huang, Bing Yang, Chun Zhou, Ting Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/34893e2e014a42498805fe529e103403
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