Sound level context modulates neural activity in the human brainstem

Abstract Optimal perception requires adaptation to sounds in the environment. Adaptation involves representing the acoustic stimulation history in neural response patterns, for example, by altering response magnitude or latency as sound-level context changes. Neurons in the auditory brainstem of rod...

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Autores principales:	Björn Herrmann, Sonia Yasmin, Kurdo Araz, David W. Purcell, Ingrid S. Johnsrude
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3489510e4e8f438e80aabb132d0895c1
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id	oai:doaj.org-article:3489510e4e8f438e80aabb132d0895c1
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spelling	oai:doaj.org-article:3489510e4e8f438e80aabb132d0895c12021-11-21T12:18:20ZSound level context modulates neural activity in the human brainstem10.1038/s41598-021-02055-y2045-2322https://doaj.org/article/3489510e4e8f438e80aabb132d0895c12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02055-yhttps://doaj.org/toc/2045-2322Abstract Optimal perception requires adaptation to sounds in the environment. Adaptation involves representing the acoustic stimulation history in neural response patterns, for example, by altering response magnitude or latency as sound-level context changes. Neurons in the auditory brainstem of rodents are sensitive to acoustic stimulation history and sound-level context (often referred to as sensitivity to stimulus statistics), but the degree to which the human brainstem exhibits such neural adaptation is unclear. In six electroencephalography experiments with over 125 participants, we demonstrate that the response latency of the human brainstem is sensitive to the history of acoustic stimulation over a few tens of milliseconds. We further show that human brainstem responses adapt to sound-level context in, at least, the last 44 ms, but that neural sensitivity to sound-level context decreases when the time window over which acoustic stimuli need to be integrated becomes wider. Our study thus provides evidence of adaptation to sound-level context in the human brainstem and of the timescale over which sound-level information affects neural responses to sound. The research delivers an important link to studies on neural adaptation in non-human animals.Björn HerrmannSonia YasminKurdo ArazDavid W. PurcellIngrid S. JohnsrudeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Björn Herrmann Sonia Yasmin Kurdo Araz David W. Purcell Ingrid S. Johnsrude Sound level context modulates neural activity in the human brainstem
description	Abstract Optimal perception requires adaptation to sounds in the environment. Adaptation involves representing the acoustic stimulation history in neural response patterns, for example, by altering response magnitude or latency as sound-level context changes. Neurons in the auditory brainstem of rodents are sensitive to acoustic stimulation history and sound-level context (often referred to as sensitivity to stimulus statistics), but the degree to which the human brainstem exhibits such neural adaptation is unclear. In six electroencephalography experiments with over 125 participants, we demonstrate that the response latency of the human brainstem is sensitive to the history of acoustic stimulation over a few tens of milliseconds. We further show that human brainstem responses adapt to sound-level context in, at least, the last 44 ms, but that neural sensitivity to sound-level context decreases when the time window over which acoustic stimuli need to be integrated becomes wider. Our study thus provides evidence of adaptation to sound-level context in the human brainstem and of the timescale over which sound-level information affects neural responses to sound. The research delivers an important link to studies on neural adaptation in non-human animals.
format	article
author	Björn Herrmann Sonia Yasmin Kurdo Araz David W. Purcell Ingrid S. Johnsrude
author_facet	Björn Herrmann Sonia Yasmin Kurdo Araz David W. Purcell Ingrid S. Johnsrude
author_sort	Björn Herrmann
title	Sound level context modulates neural activity in the human brainstem
title_short	Sound level context modulates neural activity in the human brainstem
title_full	Sound level context modulates neural activity in the human brainstem
title_fullStr	Sound level context modulates neural activity in the human brainstem
title_full_unstemmed	Sound level context modulates neural activity in the human brainstem
title_sort	sound level context modulates neural activity in the human brainstem
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3489510e4e8f438e80aabb132d0895c1
work_keys_str_mv	AT bjornherrmann soundlevelcontextmodulatesneuralactivityinthehumanbrainstem AT soniayasmin soundlevelcontextmodulatesneuralactivityinthehumanbrainstem AT kurdoaraz soundlevelcontextmodulatesneuralactivityinthehumanbrainstem AT davidwpurcell soundlevelcontextmodulatesneuralactivityinthehumanbrainstem AT ingridsjohnsrude soundlevelcontextmodulatesneuralactivityinthehumanbrainstem
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Sound level context modulates neural activity in the human brainstem

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