Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation

Uncoupling of mature oocytes from somatic granulosa cells is required for their fertilization. Here the authors show that activation of EGFR signalling in granulosa cells during ovulation triggers ERK-dependent loss of filopodia oocyte adhesion, and Arp2/3 mediated retraction of granulosa cell filop...

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Autores principales:	Laleh Abbassi, Stephany El-Hayek, Karen Freire Carvalho, Wusu Wang, Qin Yang, Sofia Granados-Aparici, Rafael Mondadori, Vilceu Bordignon, Hugh J. Clarke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/348d0733017a4b4c8fcd9963a3acfe35
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spelling	oai:doaj.org-article:348d0733017a4b4c8fcd9963a3acfe352021-12-02T13:15:07ZEpidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation10.1038/s41467-021-21644-z2041-1723https://doaj.org/article/348d0733017a4b4c8fcd9963a3acfe352021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21644-zhttps://doaj.org/toc/2041-1723Uncoupling of mature oocytes from somatic granulosa cells is required for their fertilization. Here the authors show that activation of EGFR signalling in granulosa cells during ovulation triggers ERK-dependent loss of filopodia oocyte adhesion, and Arp2/3 mediated retraction of granulosa cell filopodia.Laleh AbbassiStephany El-HayekKaren Freire CarvalhoWusu WangQin YangSofia Granados-ApariciRafael MondadoriVilceu BordignonHugh J. ClarkeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laleh Abbassi Stephany El-Hayek Karen Freire Carvalho Wusu Wang Qin Yang Sofia Granados-Aparici Rafael Mondadori Vilceu Bordignon Hugh J. Clarke Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
description	Uncoupling of mature oocytes from somatic granulosa cells is required for their fertilization. Here the authors show that activation of EGFR signalling in granulosa cells during ovulation triggers ERK-dependent loss of filopodia oocyte adhesion, and Arp2/3 mediated retraction of granulosa cell filopodia.
format	article
author	Laleh Abbassi Stephany El-Hayek Karen Freire Carvalho Wusu Wang Qin Yang Sofia Granados-Aparici Rafael Mondadori Vilceu Bordignon Hugh J. Clarke
author_facet	Laleh Abbassi Stephany El-Hayek Karen Freire Carvalho Wusu Wang Qin Yang Sofia Granados-Aparici Rafael Mondadori Vilceu Bordignon Hugh J. Clarke
author_sort	Laleh Abbassi
title	Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
title_short	Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
title_full	Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
title_fullStr	Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
title_full_unstemmed	Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
title_sort	epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/348d0733017a4b4c8fcd9963a3acfe35
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Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation

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