SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease

SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease

SGLT2 inhibitors, a class of type 2 diabetes medication, reduce cardiovascular events in patients beyond expectation from blood sugar control. Here the authors report a randomized controlled trial showing that SGLT2 inhibitors reduce inflammasome activation in peripheral macrophages, which may contr...

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Autores principales: So Ra Kim, Sang-Guk Lee, Soo Hyun Kim, Jin Hee Kim, Eunhye Choi, Wonhee Cho, John Hoon Rim, Inhwa Hwang, Chan Joo Lee, Minyoung Lee, Chang-Myung Oh, Justin Y. Jeon, Heon Yung Gee, Jeong-Ho Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Myung-Shik Lee, Je-Wook Yu, Jin Won Cho, Jung-Sun Kim, Yong-ho Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/348deff1539f49598275f21f38cec615
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spelling oai:doaj.org-article:348deff1539f49598275f21f38cec6152021-12-02T15:39:21ZSGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease10.1038/s41467-020-15983-62041-1723https://doaj.org/article/348deff1539f49598275f21f38cec6152020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15983-6https://doaj.org/toc/2041-1723SGLT2 inhibitors, a class of type 2 diabetes medication, reduce cardiovascular events in patients beyond expectation from blood sugar control. Here the authors report a randomized controlled trial showing that SGLT2 inhibitors reduce inflammasome activation in peripheral macrophages, which may contribute to the cardiovascular protection.So Ra KimSang-Guk LeeSoo Hyun KimJin Hee KimEunhye ChoiWonhee ChoJohn Hoon RimInhwa HwangChan Joo LeeMinyoung LeeChang-Myung OhJustin Y. JeonHeon Yung GeeJeong-Ho KimByung-Wan LeeEun Seok KangBong-Soo ChaMyung-Shik LeeJe-Wook YuJin Won ChoJung-Sun KimYong-ho LeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
So Ra Kim
Sang-Guk Lee
Soo Hyun Kim
Jin Hee Kim
Eunhye Choi
Wonhee Cho
John Hoon Rim
Inhwa Hwang
Chan Joo Lee
Minyoung Lee
Chang-Myung Oh
Justin Y. Jeon
Heon Yung Gee
Jeong-Ho Kim
Byung-Wan Lee
Eun Seok Kang
Bong-Soo Cha
Myung-Shik Lee
Je-Wook Yu
Jin Won Cho
Jung-Sun Kim
Yong-ho Lee
SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
description SGLT2 inhibitors, a class of type 2 diabetes medication, reduce cardiovascular events in patients beyond expectation from blood sugar control. Here the authors report a randomized controlled trial showing that SGLT2 inhibitors reduce inflammasome activation in peripheral macrophages, which may contribute to the cardiovascular protection.
format article
author So Ra Kim
Sang-Guk Lee
Soo Hyun Kim
Jin Hee Kim
Eunhye Choi
Wonhee Cho
John Hoon Rim
Inhwa Hwang
Chan Joo Lee
Minyoung Lee
Chang-Myung Oh
Justin Y. Jeon
Heon Yung Gee
Jeong-Ho Kim
Byung-Wan Lee
Eun Seok Kang
Bong-Soo Cha
Myung-Shik Lee
Je-Wook Yu
Jin Won Cho
Jung-Sun Kim
Yong-ho Lee
author_facet So Ra Kim
Sang-Guk Lee
Soo Hyun Kim
Jin Hee Kim
Eunhye Choi
Wonhee Cho
John Hoon Rim
Inhwa Hwang
Chan Joo Lee
Minyoung Lee
Chang-Myung Oh
Justin Y. Jeon
Heon Yung Gee
Jeong-Ho Kim
Byung-Wan Lee
Eun Seok Kang
Bong-Soo Cha
Myung-Shik Lee
Je-Wook Yu
Jin Won Cho
Jung-Sun Kim
Yong-ho Lee
author_sort So Ra Kim
title SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
title_short SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
title_full SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
title_fullStr SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
title_full_unstemmed SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
title_sort sglt2 inhibition modulates nlrp3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/348deff1539f49598275f21f38cec615
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