Prognostic value of radiological response to chemotherapy in patients with osteosarcoma.

<h4>Background</h4>Chemotherapy is essential to improve the prognosis of the patients with osteosarcoma, and the response to chemotherapy is an important prognostic factor. In this study, the impact of various radiological examinations on overall survival (OS) and event-free survival (EF...

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Autores principales:	Shinji Miwa, Akihiko Takeuchi, Toshiharu Shirai, Junichi Taki, Norio Yamamoto, Hideji Nishida, Katsuhiro Hayashi, Yoshikazu Tanzawa, Hiroaki Kimura, Kentaro Igarashi, Akishi Ooi, Hiroyuki Tsuchiya
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/348e6e348ffd4ee9a8f6020f34cc2df9
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spelling	oai:doaj.org-article:348e6e348ffd4ee9a8f6020f34cc2df92021-11-18T09:02:20ZPrognostic value of radiological response to chemotherapy in patients with osteosarcoma.1932-620310.1371/journal.pone.0070015https://doaj.org/article/348e6e348ffd4ee9a8f6020f34cc2df92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23922892/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Chemotherapy is essential to improve the prognosis of the patients with osteosarcoma, and the response to chemotherapy is an important prognostic factor. In this study, the impact of various radiological examinations on overall survival (OS) and event-free survival (EFS) was evaluated.<h4>Method</h4>Eighty-two patients with high-grade osteosarcoma were included in this study, and we evaluated the following factors for prognostic significance: age (≥40 years), gender (male), tumor location (truncal site), metastatic disease, histological response to chemotherapy, radiological response to chemotherapy assessed using X-ray, angiography, CT, MRI, (201)Tl scintigraphy, and (99m)Tc-MIBI scintigraphy ((99m)Tc-MIBI), and combined radiological score (CRS).<h4>Results</h4>Univariate analyses revealed that metastatic disease, histological response, (99m)Tc-MIBI, and CRS were significantly correlated with OS. Multivariate analyses showed that metastatic disease (OS: HR 35.9, P<0.001; EFS: HR 17.32, P<0.001) was an independent predictor of OS and EFS. Tumor location (HR 36.1, P = 0.003), histological response (HR 31.1, P = 0.036), and (99m)Tc-MIBI (HR 18.4, P = 0.038) were significant prognostic factors for OS. Moreover, CRS was a marginally significant predictor of OS and EFS.<h4>Conclusion</h4>The chemotherapeutic effects evaluated by (99m)Tc-MIBI and CRS could be considered as prognostic factors in osteosarcoma.Shinji MiwaAkihiko TakeuchiToshiharu ShiraiJunichi TakiNorio YamamotoHideji NishidaKatsuhiro HayashiYoshikazu TanzawaHiroaki KimuraKentaro IgarashiAkishi OoiHiroyuki TsuchiyaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e70015 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shinji Miwa Akihiko Takeuchi Toshiharu Shirai Junichi Taki Norio Yamamoto Hideji Nishida Katsuhiro Hayashi Yoshikazu Tanzawa Hiroaki Kimura Kentaro Igarashi Akishi Ooi Hiroyuki Tsuchiya Prognostic value of radiological response to chemotherapy in patients with osteosarcoma.
description	<h4>Background</h4>Chemotherapy is essential to improve the prognosis of the patients with osteosarcoma, and the response to chemotherapy is an important prognostic factor. In this study, the impact of various radiological examinations on overall survival (OS) and event-free survival (EFS) was evaluated.<h4>Method</h4>Eighty-two patients with high-grade osteosarcoma were included in this study, and we evaluated the following factors for prognostic significance: age (≥40 years), gender (male), tumor location (truncal site), metastatic disease, histological response to chemotherapy, radiological response to chemotherapy assessed using X-ray, angiography, CT, MRI, (201)Tl scintigraphy, and (99m)Tc-MIBI scintigraphy ((99m)Tc-MIBI), and combined radiological score (CRS).<h4>Results</h4>Univariate analyses revealed that metastatic disease, histological response, (99m)Tc-MIBI, and CRS were significantly correlated with OS. Multivariate analyses showed that metastatic disease (OS: HR 35.9, P<0.001; EFS: HR 17.32, P<0.001) was an independent predictor of OS and EFS. Tumor location (HR 36.1, P = 0.003), histological response (HR 31.1, P = 0.036), and (99m)Tc-MIBI (HR 18.4, P = 0.038) were significant prognostic factors for OS. Moreover, CRS was a marginally significant predictor of OS and EFS.<h4>Conclusion</h4>The chemotherapeutic effects evaluated by (99m)Tc-MIBI and CRS could be considered as prognostic factors in osteosarcoma.
format	article
author	Shinji Miwa Akihiko Takeuchi Toshiharu Shirai Junichi Taki Norio Yamamoto Hideji Nishida Katsuhiro Hayashi Yoshikazu Tanzawa Hiroaki Kimura Kentaro Igarashi Akishi Ooi Hiroyuki Tsuchiya
author_facet	Shinji Miwa Akihiko Takeuchi Toshiharu Shirai Junichi Taki Norio Yamamoto Hideji Nishida Katsuhiro Hayashi Yoshikazu Tanzawa Hiroaki Kimura Kentaro Igarashi Akishi Ooi Hiroyuki Tsuchiya
author_sort	Shinji Miwa
title	Prognostic value of radiological response to chemotherapy in patients with osteosarcoma.
title_short	Prognostic value of radiological response to chemotherapy in patients with osteosarcoma.
title_full	Prognostic value of radiological response to chemotherapy in patients with osteosarcoma.
title_fullStr	Prognostic value of radiological response to chemotherapy in patients with osteosarcoma.
title_full_unstemmed	Prognostic value of radiological response to chemotherapy in patients with osteosarcoma.
title_sort	prognostic value of radiological response to chemotherapy in patients with osteosarcoma.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/348e6e348ffd4ee9a8f6020f34cc2df9
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Prognostic value of radiological response to chemotherapy in patients with osteosarcoma.

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