Epsin-mediated degradation of IP3R1 fuels atherosclerosis

Endothelial cell (EC) dysfunction and inflammation contribute to plaque destabilization in atherosclerosis, increasing the risk of thrombotic events. Here, the authors show that epsin promotes EC inflammation via a mechanism involving IP3R1 degradation, and that deletion of epsin in the endothelium...

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Autores principales:	Yunzhou Dong, Yang Lee, Kui Cui, Ming He, Beibei Wang, Sudarshan Bhattacharjee, Bo Zhu, Tadayuki Yago, Kun Zhang, Lin Deng, Kunfu Ouyang, Aiyun Wen, Douglas B. Cowan, Kai Song, Lili Yu, Megan L. Brophy, Xiaolei Liu, Jill Wylie-Sears, Hao Wu, Scott Wong, Guanglin Cui, Yusuke Kawashima, Hiroyuki Matsumoto, Yoshio Kodera, Richard J. H. Wojcikiewicz, Sanjay Srivastava, Joyce Bischoff, Da-Zhi Wang, Klaus Ley, Hong Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/348ebe71d77b44b0a5e82d323a1c1b08
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spelling	oai:doaj.org-article:348ebe71d77b44b0a5e82d323a1c1b082021-12-02T18:49:35ZEpsin-mediated degradation of IP3R1 fuels atherosclerosis10.1038/s41467-020-17848-42041-1723https://doaj.org/article/348ebe71d77b44b0a5e82d323a1c1b082020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17848-4https://doaj.org/toc/2041-1723Endothelial cell (EC) dysfunction and inflammation contribute to plaque destabilization in atherosclerosis, increasing the risk of thrombotic events. Here, the authors show that epsin promotes EC inflammation via a mechanism involving IP3R1 degradation, and that deletion of epsin in the endothelium prevents EC dysfunctoin and atherosclerosis in mice.Yunzhou DongYang LeeKui CuiMing HeBeibei WangSudarshan BhattacharjeeBo ZhuTadayuki YagoKun ZhangLin DengKunfu OuyangAiyun WenDouglas B. CowanKai SongLili YuMegan L. BrophyXiaolei LiuJill Wylie-SearsHao WuScott WongGuanglin CuiYusuke KawashimaHiroyuki MatsumotoYoshio KoderaRichard J. H. WojcikiewiczSanjay SrivastavaJoyce BischoffDa-Zhi WangKlaus LeyHong ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunzhou Dong Yang Lee Kui Cui Ming He Beibei Wang Sudarshan Bhattacharjee Bo Zhu Tadayuki Yago Kun Zhang Lin Deng Kunfu Ouyang Aiyun Wen Douglas B. Cowan Kai Song Lili Yu Megan L. Brophy Xiaolei Liu Jill Wylie-Sears Hao Wu Scott Wong Guanglin Cui Yusuke Kawashima Hiroyuki Matsumoto Yoshio Kodera Richard J. H. Wojcikiewicz Sanjay Srivastava Joyce Bischoff Da-Zhi Wang Klaus Ley Hong Chen Epsin-mediated degradation of IP3R1 fuels atherosclerosis
description	Endothelial cell (EC) dysfunction and inflammation contribute to plaque destabilization in atherosclerosis, increasing the risk of thrombotic events. Here, the authors show that epsin promotes EC inflammation via a mechanism involving IP3R1 degradation, and that deletion of epsin in the endothelium prevents EC dysfunctoin and atherosclerosis in mice.
format	article
author	Yunzhou Dong Yang Lee Kui Cui Ming He Beibei Wang Sudarshan Bhattacharjee Bo Zhu Tadayuki Yago Kun Zhang Lin Deng Kunfu Ouyang Aiyun Wen Douglas B. Cowan Kai Song Lili Yu Megan L. Brophy Xiaolei Liu Jill Wylie-Sears Hao Wu Scott Wong Guanglin Cui Yusuke Kawashima Hiroyuki Matsumoto Yoshio Kodera Richard J. H. Wojcikiewicz Sanjay Srivastava Joyce Bischoff Da-Zhi Wang Klaus Ley Hong Chen
author_facet	Yunzhou Dong Yang Lee Kui Cui Ming He Beibei Wang Sudarshan Bhattacharjee Bo Zhu Tadayuki Yago Kun Zhang Lin Deng Kunfu Ouyang Aiyun Wen Douglas B. Cowan Kai Song Lili Yu Megan L. Brophy Xiaolei Liu Jill Wylie-Sears Hao Wu Scott Wong Guanglin Cui Yusuke Kawashima Hiroyuki Matsumoto Yoshio Kodera Richard J. H. Wojcikiewicz Sanjay Srivastava Joyce Bischoff Da-Zhi Wang Klaus Ley Hong Chen
author_sort	Yunzhou Dong
title	Epsin-mediated degradation of IP3R1 fuels atherosclerosis
title_short	Epsin-mediated degradation of IP3R1 fuels atherosclerosis
title_full	Epsin-mediated degradation of IP3R1 fuels atherosclerosis
title_fullStr	Epsin-mediated degradation of IP3R1 fuels atherosclerosis
title_full_unstemmed	Epsin-mediated degradation of IP3R1 fuels atherosclerosis
title_sort	epsin-mediated degradation of ip3r1 fuels atherosclerosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/348ebe71d77b44b0a5e82d323a1c1b08
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Epsin-mediated degradation of IP3R1 fuels atherosclerosis

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