Antidiabetic effect of glucosaminic acid-cobalt (II) chelate in streptozotocin-induced diabetes in mice

Tahirou Talba1, Xia Wen Shui1, Qinyuan Cheng1,2, Xin Tian21Key Laboratory of Food Processing Technology, 2School of Medicine and Pharmaceutics, Jiangnan University, Wuxi, Jiangsu, People&#39;s Republic of ChinaBackground: The purpose of this study was to assess the in vivo ability of glucosa...

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Autores principales:	Talba T, Shui XW, Cheng QY, Tian X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/349049988ba142748264ec99f58cd9d6
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spelling	oai:doaj.org-article:349049988ba142748264ec99f58cd9d62021-12-02T00:42:47ZAntidiabetic effect of glucosaminic acid-cobalt (II) chelate in streptozotocin-induced diabetes in mice1178-7007https://doaj.org/article/349049988ba142748264ec99f58cd9d62011-04-01T00:00:00Zhttp://www.dovepress.com/antidiabetic-effect-of-glucosaminic-acid-cobalt-ii-chelate-in-streptoz-a7127https://doaj.org/toc/1178-7007Tahirou Talba1, Xia Wen Shui1, Qinyuan Cheng1,2, Xin Tian21Key Laboratory of Food Processing Technology, 2School of Medicine and Pharmaceutics, Jiangnan University, Wuxi, Jiangsu, People&#39;s Republic of ChinaBackground: The purpose of this study was to assess the in vivo ability of glucosaminic acid-cobalt (II) chelate to reduce glycemia.Methods: Different concentrations of chelate solution were administrated to mice with diabetes induced by streptozotocin. Daily oral administration of chelate solution 0.4 mL at various concentrations (0.32&ndash;0.4 g/mL) led to reduction in water intake by the diabetic mice after 5 days of treatment, with a subsequent reduction in glucose levels observed 2 weeks later. Daily food intake was related to both chelate concentration as well as glycemia reduction. The food intake of mice treated with glucosaminic acid-cobalt (II) chelate solution was 1.5-fold that of untreated mice.Keywords: glucosaminic acid, cobalt, chelate, streptozotocin, glycemia reduction Talba TShui XWCheng QYTian XDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2011, Iss default, Pp 137-140 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Talba T Shui XW Cheng QY Tian X Antidiabetic effect of glucosaminic acid-cobalt (II) chelate in streptozotocin-induced diabetes in mice
description	Tahirou Talba1, Xia Wen Shui1, Qinyuan Cheng1,2, Xin Tian21Key Laboratory of Food Processing Technology, 2School of Medicine and Pharmaceutics, Jiangnan University, Wuxi, Jiangsu, People&#39;s Republic of ChinaBackground: The purpose of this study was to assess the in vivo ability of glucosaminic acid-cobalt (II) chelate to reduce glycemia.Methods: Different concentrations of chelate solution were administrated to mice with diabetes induced by streptozotocin. Daily oral administration of chelate solution 0.4 mL at various concentrations (0.32&ndash;0.4 g/mL) led to reduction in water intake by the diabetic mice after 5 days of treatment, with a subsequent reduction in glucose levels observed 2 weeks later. Daily food intake was related to both chelate concentration as well as glycemia reduction. The food intake of mice treated with glucosaminic acid-cobalt (II) chelate solution was 1.5-fold that of untreated mice.Keywords: glucosaminic acid, cobalt, chelate, streptozotocin, glycemia reduction
format	article
author	Talba T Shui XW Cheng QY Tian X
author_facet	Talba T Shui XW Cheng QY Tian X
author_sort	Talba T
title	Antidiabetic effect of glucosaminic acid-cobalt (II) chelate in streptozotocin-induced diabetes in mice
title_short	Antidiabetic effect of glucosaminic acid-cobalt (II) chelate in streptozotocin-induced diabetes in mice
title_full	Antidiabetic effect of glucosaminic acid-cobalt (II) chelate in streptozotocin-induced diabetes in mice
title_fullStr	Antidiabetic effect of glucosaminic acid-cobalt (II) chelate in streptozotocin-induced diabetes in mice
title_full_unstemmed	Antidiabetic effect of glucosaminic acid-cobalt (II) chelate in streptozotocin-induced diabetes in mice
title_sort	antidiabetic effect of glucosaminic acid-cobalt (ii) chelate in streptozotocin-induced diabetes in mice
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/349049988ba142748264ec99f58cd9d6
work_keys_str_mv	AT talbat antidiabeticeffectofglucosaminicacidcobaltiichelateinstreptozotocininduceddiabetesinmice AT shuixw antidiabeticeffectofglucosaminicacidcobaltiichelateinstreptozotocininduceddiabetesinmice AT chengqy antidiabeticeffectofglucosaminicacidcobaltiichelateinstreptozotocininduceddiabetesinmice AT tianx antidiabeticeffectofglucosaminicacidcobaltiichelateinstreptozotocininduceddiabetesinmice
_version_	1718403484687007744

Antidiabetic effect of glucosaminic acid-cobalt (II) chelate in streptozotocin-induced diabetes in mice

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