Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Jing Xiao, Weijun Chen, Xinhui Feng, Wenyi Liu, Zhenxing Zhang, Li He, Zhibin Ye Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China Objectives: We aimed to investigate the association of serum uric acid (UA) levels with bone mi...

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Autores principales:	Xiao J, Chen WJ, Feng XH, Liu WY, Zhang ZX, He L, Ye ZB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	uric acid bone mineral density T value lumbar spine Chinese. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/3490a3ff1b82486b8dc3a129b4d6286e
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spelling	oai:doaj.org-article:3490a3ff1b82486b8dc3a129b4d6286e2021-12-02T01:04:34ZSerum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years1178-1998https://doaj.org/article/3490a3ff1b82486b8dc3a129b4d6286e2017-02-01T00:00:00Zhttps://www.dovepress.com/serum-uric-acid-is-associated-with-lumbar-spine-bone-mineral-density-i-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jing Xiao, Weijun Chen, Xinhui Feng, Wenyi Liu, Zhenxing Zhang, Li He, Zhibin Ye Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China Objectives: We aimed to investigate the association of serum uric acid (UA) levels with bone mineral density (BMD) at all skeletal sites in healthy Chinese males >50 years of age. Methods: A cross-sectional study of 385 Chinese males >50 years of age who underwent health checkup in Huadong Hospital Affiliated to Fudan University in Shanghai, China, was conducted. Clinical and bone characteristics were compared in different UA tertiles (UA1: UA <4.7 mg/dL, UA2: 4.7 mg/dL ≤ UA <6 mg/dL and UA3: UA ≥6 mg/dL). Pearson correlation and multiple regression analysis were used to study the correlation of UA with BMD at various skeletal sites. Results: Serum UA levels were positively associated with higher BMD and T-values at the lumbar spine, but not at other skeletal sites, after adjusting for multiple confounding factors. Lumbar spine BMD; the T- and Z-values at the lumbar spine, total hip and femoral neck; as well as intact parathyroid hormone (iPTH) levels are higher in the highest tertile of UA than in the second tertile of UA. Conclusion: Our results provide epidemiological evidence in Chinese Han males aged >50 years that serum UA levels are positively correlated with lumbar spine BMD and T-values, suggesting that UA may exert protective effect on bone density at the lumbar spine in Chinese males >50 years of age. Keywords: T-value, Z-value, parathyroid hormone, bone turnover markerXiao JChen WJFeng XHLiu WYZhang ZXHe LYe ZBDove Medical Pressarticleuric acidbone mineral densityT valuelumbar spineChinese.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 445-452 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	uric acid bone mineral density T value lumbar spine Chinese. Geriatrics RC952-954.6
spellingShingle	uric acid bone mineral density T value lumbar spine Chinese. Geriatrics RC952-954.6 Xiao J Chen WJ Feng XH Liu WY Zhang ZX He L Ye ZB Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years
description	Jing Xiao, Weijun Chen, Xinhui Feng, Wenyi Liu, Zhenxing Zhang, Li He, Zhibin Ye Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China Objectives: We aimed to investigate the association of serum uric acid (UA) levels with bone mineral density (BMD) at all skeletal sites in healthy Chinese males >50 years of age. Methods: A cross-sectional study of 385 Chinese males >50 years of age who underwent health checkup in Huadong Hospital Affiliated to Fudan University in Shanghai, China, was conducted. Clinical and bone characteristics were compared in different UA tertiles (UA1: UA <4.7 mg/dL, UA2: 4.7 mg/dL ≤ UA <6 mg/dL and UA3: UA ≥6 mg/dL). Pearson correlation and multiple regression analysis were used to study the correlation of UA with BMD at various skeletal sites. Results: Serum UA levels were positively associated with higher BMD and T-values at the lumbar spine, but not at other skeletal sites, after adjusting for multiple confounding factors. Lumbar spine BMD; the T- and Z-values at the lumbar spine, total hip and femoral neck; as well as intact parathyroid hormone (iPTH) levels are higher in the highest tertile of UA than in the second tertile of UA. Conclusion: Our results provide epidemiological evidence in Chinese Han males aged >50 years that serum UA levels are positively correlated with lumbar spine BMD and T-values, suggesting that UA may exert protective effect on bone density at the lumbar spine in Chinese males >50 years of age. Keywords: T-value, Z-value, parathyroid hormone, bone turnover marker
format	article
author	Xiao J Chen WJ Feng XH Liu WY Zhang ZX He L Ye ZB
author_facet	Xiao J Chen WJ Feng XH Liu WY Zhang ZX He L Ye ZB
author_sort	Xiao J
title	Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years
title_short	Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years
title_full	Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years
title_fullStr	Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years
title_full_unstemmed	Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years
title_sort	serum uric acid is associated with lumbar spine bone mineral density in healthy chinese males older than 50 years
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/3490a3ff1b82486b8dc3a129b4d6286e
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Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

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