Perfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine
Lina Wu,1,2,* Fang Liu,1,3,* Shuang Liu,1,2,* Xiuan Xu,1,3 Zhaoxi Liu,1,2 Xilin Sun1,2 1NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of China; 2T...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2020
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| Acceso en línea: | https://doaj.org/article/34941a4e02c043528082d62901400505 |
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| Sumario: | Lina Wu,1,2,* Fang Liu,1,3,* Shuang Liu,1,2,* Xiuan Xu,1,3 Zhaoxi Liu,1,2 Xilin Sun1,2 1NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of China; 2TOF-PET/CT/MR Center, Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of China; 3Department of Medical Imaging, Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xilin SunMolecular Imaging Research Center of Harbin Medical University (MIRC), TOF-PET/CT/MR Center, Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of ChinaFax +86 451-82576509Email sunxl@ems.hrbmu.edu.cnAbstract: Fluorine-19 (19F) magnetic resonance (MR) molecular imaging is a promising noninvasive and quantitative molecular imaging approach with intensive research due to the high sensitivity and low endogenous background signal of the 19F atom in vivo. Perfluorocarbons (PFCs) have been used as blood substitutes since 1970s. More recently, a variety of PFC nanoparticles have been designed for the detection and imaging of physiological and pathological changes. These molecular imaging probes have been developed to label cells, target specific epitopes in tumors, monitor the prognosis and therapy efficacy and quantitate characterization of tumors and changes in tumor microenvironment noninvasively, therefore, significantly improving the prognosis and therapy efficacy. Herein, we discuss the recent development and applications of 19F MR techniques with PFC nanoparticles in biomedicine, with particular emphasis on ligand-targeted and quantitative 19F MR imaging approaches for tumor detection, oxygenation measurement, smart stimulus response and therapy efficacy monitoring, et al.Keywords: fluorine-19 magnetic resonance imaging, fluorocarbons, nanoparticles, molecular imaging, neoplasms |
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