Perfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine

Lina Wu,1,2,* Fang Liu,1,3,* Shuang Liu,1,2,* Xiuan Xu,1,3 Zhaoxi Liu,1,2 Xilin Sun1,2 1NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of China; 2T...

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Autores principales:	Wu L, Liu F, Liu S, Xu X, Liu Z, Sun X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	fluorine-19 magnetic resonance imaging fluorocarbons nanoparticles molecular imaging neoplasms Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/34941a4e02c043528082d62901400505
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spelling	oai:doaj.org-article:34941a4e02c043528082d629014005052021-12-02T10:21:46ZPerfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine1178-2013https://doaj.org/article/34941a4e02c043528082d629014005052020-10-01T00:00:00Zhttps://www.dovepress.com/perfluorocarbons-based-19f-magnetic-resonance-imaging-in-biomedicine-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Lina Wu,1,2,* Fang Liu,1,3,* Shuang Liu,1,2,* Xiuan Xu,1,3 Zhaoxi Liu,1,2 Xilin Sun1,2 1NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of China; 2TOF-PET/CT/MR Center, Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of China; 3Department of Medical Imaging, Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xilin SunMolecular Imaging Research Center of Harbin Medical University (MIRC), TOF-PET/CT/MR Center, Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of ChinaFax +86 451-82576509Email sunxl@ems.hrbmu.edu.cnAbstract: Fluorine-19 (19F) magnetic resonance (MR) molecular imaging is a promising noninvasive and quantitative molecular imaging approach with intensive research due to the high sensitivity and low endogenous background signal of the 19F atom in vivo. Perfluorocarbons (PFCs) have been used as blood substitutes since 1970s. More recently, a variety of PFC nanoparticles have been designed for the detection and imaging of physiological and pathological changes. These molecular imaging probes have been developed to label cells, target specific epitopes in tumors, monitor the prognosis and therapy efficacy and quantitate characterization of tumors and changes in tumor microenvironment noninvasively, therefore, significantly improving the prognosis and therapy efficacy. Herein, we discuss the recent development and applications of 19F MR techniques with PFC nanoparticles in biomedicine, with particular emphasis on ligand-targeted and quantitative 19F MR imaging approaches for tumor detection, oxygenation measurement, smart stimulus response and therapy efficacy monitoring, et al.Keywords: fluorine-19 magnetic resonance imaging, fluorocarbons, nanoparticles, molecular imaging, neoplasmsWu LLiu FLiu SXu XLiu ZSun XDove Medical Pressarticlefluorine-19 magnetic resonance imagingfluorocarbonsnanoparticlesmolecular imagingneoplasmsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 7377-7395 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	fluorine-19 magnetic resonance imaging fluorocarbons nanoparticles molecular imaging neoplasms Medicine (General) R5-920
spellingShingle	fluorine-19 magnetic resonance imaging fluorocarbons nanoparticles molecular imaging neoplasms Medicine (General) R5-920 Wu L Liu F Liu S Xu X Liu Z Sun X Perfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine
description	Lina Wu,1,2,* Fang Liu,1,3,* Shuang Liu,1,2,* Xiuan Xu,1,3 Zhaoxi Liu,1,2 Xilin Sun1,2 1NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of China; 2TOF-PET/CT/MR Center, Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of China; 3Department of Medical Imaging, Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xilin SunMolecular Imaging Research Center of Harbin Medical University (MIRC), TOF-PET/CT/MR Center, Harbin Medical University, Harbin, Heilongjiang 150028, People’s Republic of ChinaFax +86 451-82576509Email sunxl@ems.hrbmu.edu.cnAbstract: Fluorine-19 (19F) magnetic resonance (MR) molecular imaging is a promising noninvasive and quantitative molecular imaging approach with intensive research due to the high sensitivity and low endogenous background signal of the 19F atom in vivo. Perfluorocarbons (PFCs) have been used as blood substitutes since 1970s. More recently, a variety of PFC nanoparticles have been designed for the detection and imaging of physiological and pathological changes. These molecular imaging probes have been developed to label cells, target specific epitopes in tumors, monitor the prognosis and therapy efficacy and quantitate characterization of tumors and changes in tumor microenvironment noninvasively, therefore, significantly improving the prognosis and therapy efficacy. Herein, we discuss the recent development and applications of 19F MR techniques with PFC nanoparticles in biomedicine, with particular emphasis on ligand-targeted and quantitative 19F MR imaging approaches for tumor detection, oxygenation measurement, smart stimulus response and therapy efficacy monitoring, et al.Keywords: fluorine-19 magnetic resonance imaging, fluorocarbons, nanoparticles, molecular imaging, neoplasms
format	article
author	Wu L Liu F Liu S Xu X Liu Z Sun X
author_facet	Wu L Liu F Liu S Xu X Liu Z Sun X
author_sort	Wu L
title	Perfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine
title_short	Perfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine
title_full	Perfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine
title_fullStr	Perfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine
title_full_unstemmed	Perfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine
title_sort	perfluorocarbons-based 19f magnetic resonance imaging in biomedicine
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/34941a4e02c043528082d62901400505
work_keys_str_mv	AT wul perfluorocarbonsbased19fmagneticresonanceimaginginbiomedicine AT liuf perfluorocarbonsbased19fmagneticresonanceimaginginbiomedicine AT lius perfluorocarbonsbased19fmagneticresonanceimaginginbiomedicine AT xux perfluorocarbonsbased19fmagneticresonanceimaginginbiomedicine AT liuz perfluorocarbonsbased19fmagneticresonanceimaginginbiomedicine AT sunx perfluorocarbonsbased19fmagneticresonanceimaginginbiomedicine
_version_	1718397336572395520

Perfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine

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