The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1

The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1

The T300A substitution in ATG16L is associated with Crohn’s disease risk and disrupts clearance of intracellular pathogens by autophagy. Here the authors show that the mutation impairs interaction of ATG16L with TMEM59 and disrupts unconventional TMEM-induced autophagy, an aspect of innate immunity....

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Autores principales: Emilio Boada-Romero, Inmaculada Serramito-Gómez, María P. Sacristán, David L. Boone, Ramnik J. Xavier, Felipe X. Pimentel-Muiños
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/34956e407de4444e99fd297358803333
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spelling oai:doaj.org-article:34956e407de4444e99fd2973588033332021-12-02T16:49:42ZThe T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L110.1038/ncomms118212041-1723https://doaj.org/article/34956e407de4444e99fd2973588033332016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11821https://doaj.org/toc/2041-1723The T300A substitution in ATG16L is associated with Crohn’s disease risk and disrupts clearance of intracellular pathogens by autophagy. Here the authors show that the mutation impairs interaction of ATG16L with TMEM59 and disrupts unconventional TMEM-induced autophagy, an aspect of innate immunity.Emilio Boada-RomeroInmaculada Serramito-GómezMaría P. SacristánDavid L. BooneRamnik J. XavierFelipe X. Pimentel-MuiñosNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Emilio Boada-Romero
Inmaculada Serramito-Gómez
María P. Sacristán
David L. Boone
Ramnik J. Xavier
Felipe X. Pimentel-Muiños
The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1
description The T300A substitution in ATG16L is associated with Crohn’s disease risk and disrupts clearance of intracellular pathogens by autophagy. Here the authors show that the mutation impairs interaction of ATG16L with TMEM59 and disrupts unconventional TMEM-induced autophagy, an aspect of innate immunity.
format article
author Emilio Boada-Romero
Inmaculada Serramito-Gómez
María P. Sacristán
David L. Boone
Ramnik J. Xavier
Felipe X. Pimentel-Muiños
author_facet Emilio Boada-Romero
Inmaculada Serramito-Gómez
María P. Sacristán
David L. Boone
Ramnik J. Xavier
Felipe X. Pimentel-Muiños
author_sort Emilio Boada-Romero
title The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1
title_short The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1
title_full The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1
title_fullStr The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1
title_full_unstemmed The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1
title_sort t300a crohn’s disease risk polymorphism impairs function of the wd40 domain of atg16l1
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/34956e407de4444e99fd297358803333
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