Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis

Inonotus obliquus Polysaccharide (IOP) is a large molecule extracted from Inonotus obliqus, a medicinal fungus, which has a wide range of biological activities and has been shown to be associated with inflammation. The purpose of this study is to investigate whether IOP can help to reduce acute endo...

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Autores principales:	Binhong Hu, Yuqing Dong, Wenjing Zhou, Yichuan Ma, Luyao Li, Xianhua Fu, Wenxuan Zhang, Yuanyue Luo, Jingyu Pu, Xin Deng, Rong Zhang, Songqing Liu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3495a94b37bc42e2ae8199cb2f57ff3e
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spelling	oai:doaj.org-article:3495a94b37bc42e2ae8199cb2f57ff3e2021-11-11T07:51:49ZEffect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis1932-6203https://doaj.org/article/3495a94b37bc42e2ae8199cb2f57ff3e2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570517/?tool=EBIhttps://doaj.org/toc/1932-6203Inonotus obliquus Polysaccharide (IOP) is a large molecule extracted from Inonotus obliqus, a medicinal fungus, which has a wide range of biological activities and has been shown to be associated with inflammation. The purpose of this study is to investigate whether IOP can help to reduce acute endometritis by regulating intestinal flora. We observed pathological changes in mice with endometritis following treatment with IOP and evaluated changes in the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α), and further studied the effects of IOP on the intestinal flora of endometritis mice using 16S rRNA high-throughput sequencing. The results showed that IOP improved the condition of uterine tissues and reduced the release of pro-inflammatory cytokines. Meanwhile, the 16S rRNA sequencing results showed that IOP could regulate the changes in intestinal microflora at the level of genera, possibly by changing the relative abundance of some genera.Binhong HuYuqing DongWenjing ZhouYichuan MaLuyao LiXianhua FuWenxuan ZhangYuanyue LuoJingyu PuXin DengRong ZhangSongqing LiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Binhong Hu Yuqing Dong Wenjing Zhou Yichuan Ma Luyao Li Xianhua Fu Wenxuan Zhang Yuanyue Luo Jingyu Pu Xin Deng Rong Zhang Songqing Liu Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis
description	Inonotus obliquus Polysaccharide (IOP) is a large molecule extracted from Inonotus obliqus, a medicinal fungus, which has a wide range of biological activities and has been shown to be associated with inflammation. The purpose of this study is to investigate whether IOP can help to reduce acute endometritis by regulating intestinal flora. We observed pathological changes in mice with endometritis following treatment with IOP and evaluated changes in the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α), and further studied the effects of IOP on the intestinal flora of endometritis mice using 16S rRNA high-throughput sequencing. The results showed that IOP improved the condition of uterine tissues and reduced the release of pro-inflammatory cytokines. Meanwhile, the 16S rRNA sequencing results showed that IOP could regulate the changes in intestinal microflora at the level of genera, possibly by changing the relative abundance of some genera.
format	article
author	Binhong Hu Yuqing Dong Wenjing Zhou Yichuan Ma Luyao Li Xianhua Fu Wenxuan Zhang Yuanyue Luo Jingyu Pu Xin Deng Rong Zhang Songqing Liu
author_facet	Binhong Hu Yuqing Dong Wenjing Zhou Yichuan Ma Luyao Li Xianhua Fu Wenxuan Zhang Yuanyue Luo Jingyu Pu Xin Deng Rong Zhang Songqing Liu
author_sort	Binhong Hu
title	Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis
title_short	Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis
title_full	Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis
title_fullStr	Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis
title_full_unstemmed	Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis
title_sort	effect of inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3495a94b37bc42e2ae8199cb2f57ff3e
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Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis

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