Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis

It is unclear if multiple sclerosis (MS) genetic susceptibility can be mediated through perturbations of CNS-intrinsic pathways. Authors show that the rs7665090 risk variant is associated with astrocyte responses that enhance lymphocyte recruitment, and with increased lymphocyte infiltration and les...

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Autores principales:	Gerald Ponath, Matthew R. Lincoln, Maya Levine-Ritterman, Calvin Park, Somiah Dahlawi, Mayyan Mubarak, Tomokazu Sumida, Laura Airas, Shun Zhang, Cigdem Isitan, Thanh D. Nguyen, Cedric S. Raine, David A. Hafler, David Pitt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/34975c90ae204b8282c217e372c0f104
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spelling	oai:doaj.org-article:34975c90ae204b8282c217e372c0f1042021-12-02T15:33:57ZEnhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis10.1038/s41467-018-07785-82041-1723https://doaj.org/article/34975c90ae204b8282c217e372c0f1042018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07785-8https://doaj.org/toc/2041-1723It is unclear if multiple sclerosis (MS) genetic susceptibility can be mediated through perturbations of CNS-intrinsic pathways. Authors show that the rs7665090 risk variant is associated with astrocyte responses that enhance lymphocyte recruitment, and with increased lymphocyte infiltration and lesion sizes in MS lesions.Gerald PonathMatthew R. LincolnMaya Levine-RittermanCalvin ParkSomiah DahlawiMayyan MubarakTomokazu SumidaLaura AirasShun ZhangCigdem IsitanThanh D. NguyenCedric S. RaineDavid A. HaflerDavid PittNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gerald Ponath Matthew R. Lincoln Maya Levine-Ritterman Calvin Park Somiah Dahlawi Mayyan Mubarak Tomokazu Sumida Laura Airas Shun Zhang Cigdem Isitan Thanh D. Nguyen Cedric S. Raine David A. Hafler David Pitt Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis
description	It is unclear if multiple sclerosis (MS) genetic susceptibility can be mediated through perturbations of CNS-intrinsic pathways. Authors show that the rs7665090 risk variant is associated with astrocyte responses that enhance lymphocyte recruitment, and with increased lymphocyte infiltration and lesion sizes in MS lesions.
format	article
author	Gerald Ponath Matthew R. Lincoln Maya Levine-Ritterman Calvin Park Somiah Dahlawi Mayyan Mubarak Tomokazu Sumida Laura Airas Shun Zhang Cigdem Isitan Thanh D. Nguyen Cedric S. Raine David A. Hafler David Pitt
author_facet	Gerald Ponath Matthew R. Lincoln Maya Levine-Ritterman Calvin Park Somiah Dahlawi Mayyan Mubarak Tomokazu Sumida Laura Airas Shun Zhang Cigdem Isitan Thanh D. Nguyen Cedric S. Raine David A. Hafler David Pitt
author_sort	Gerald Ponath
title	Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis
title_short	Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis
title_full	Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis
title_fullStr	Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis
title_full_unstemmed	Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis
title_sort	enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/34975c90ae204b8282c217e372c0f104
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Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis

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