Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis

It is unclear if multiple sclerosis (MS) genetic susceptibility can be mediated through perturbations of CNS-intrinsic pathways. Authors show that the rs7665090 risk variant is associated with astrocyte responses that enhance lymphocyte recruitment, and with increased lymphocyte infiltration and les...

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Bibliographic Details
Main Authors: Gerald Ponath, Matthew R. Lincoln, Maya Levine-Ritterman, Calvin Park, Somiah Dahlawi, Mayyan Mubarak, Tomokazu Sumida, Laura Airas, Shun Zhang, Cigdem Isitan, Thanh D. Nguyen, Cedric S. Raine, David A. Hafler, David Pitt
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/34975c90ae204b8282c217e372c0f104
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https://doaj.org/article/34975c90ae204b8282c217e372c0f104

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