Effects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy

Abstract Vertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries for the remission of obesity and diabetes. Its effects include weight loss, improved insulin resistance, and the improvement of hepatic steatosis. Epidemiologic studies demonstrated that vit...

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Autores principales:	Jie Zhang, Min Feng, Lisha Pan, Feng Wang, Pengfei Wu, Yang You, Meiyun Hua, Tianci Zhang, Zheng Wang, Liang Zong, Yuanping Han, Wenxian Guan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/349cca77a7354e32aeb5b2b2d6187d41
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spelling	oai:doaj.org-article:349cca77a7354e32aeb5b2b2d6187d412021-12-02T17:05:45ZEffects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy10.1038/s41598-021-85531-92045-2322https://doaj.org/article/349cca77a7354e32aeb5b2b2d6187d412021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85531-9https://doaj.org/toc/2045-2322Abstract Vertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries for the remission of obesity and diabetes. Its effects include weight loss, improved insulin resistance, and the improvement of hepatic steatosis. Epidemiologic studies demonstrated that vitamin D deficiency (VDD) is associated with many diseases, including obesity. To explore the role of vitamin D in metabolic disorders for patients with obesity after VSG. We established a murine model of diet-induced obesity + VDD, and we performed VSGs to investigate VDD's effects on the improvement of metabolic disorders present in post-VSG obese mice. We observed that in HFD mice, the concentration of VitD3 is four fold of HFD + VDD one. In the post-VSG obese mice, VDD attenuated the improvements of hepatic steatosis, insulin resistance, intestinal inflammation and permeability, the maintenance of weight loss, the reduction of fat loss, and the restoration of intestinal flora that were weakened. Our results suggest that in post-VSG obese mice, maintaining a normal level of vitamin D plays an important role in maintaining the improvement of metabolic disorders.Jie ZhangMin FengLisha PanFeng WangPengfei WuYang YouMeiyun HuaTianci ZhangZheng WangLiang ZongYuanping HanWenxian GuanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jie Zhang Min Feng Lisha Pan Feng Wang Pengfei Wu Yang You Meiyun Hua Tianci Zhang Zheng Wang Liang Zong Yuanping Han Wenxian Guan Effects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy
description	Abstract Vertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries for the remission of obesity and diabetes. Its effects include weight loss, improved insulin resistance, and the improvement of hepatic steatosis. Epidemiologic studies demonstrated that vitamin D deficiency (VDD) is associated with many diseases, including obesity. To explore the role of vitamin D in metabolic disorders for patients with obesity after VSG. We established a murine model of diet-induced obesity + VDD, and we performed VSGs to investigate VDD's effects on the improvement of metabolic disorders present in post-VSG obese mice. We observed that in HFD mice, the concentration of VitD3 is four fold of HFD + VDD one. In the post-VSG obese mice, VDD attenuated the improvements of hepatic steatosis, insulin resistance, intestinal inflammation and permeability, the maintenance of weight loss, the reduction of fat loss, and the restoration of intestinal flora that were weakened. Our results suggest that in post-VSG obese mice, maintaining a normal level of vitamin D plays an important role in maintaining the improvement of metabolic disorders.
format	article
author	Jie Zhang Min Feng Lisha Pan Feng Wang Pengfei Wu Yang You Meiyun Hua Tianci Zhang Zheng Wang Liang Zong Yuanping Han Wenxian Guan
author_facet	Jie Zhang Min Feng Lisha Pan Feng Wang Pengfei Wu Yang You Meiyun Hua Tianci Zhang Zheng Wang Liang Zong Yuanping Han Wenxian Guan
author_sort	Jie Zhang
title	Effects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy
title_short	Effects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy
title_full	Effects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy
title_fullStr	Effects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy
title_full_unstemmed	Effects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy
title_sort	effects of vitamin d deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/349cca77a7354e32aeb5b2b2d6187d41
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Effects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy

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