Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence.

Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence.

Four sequential Aspergillus fumigatus isolates from a patient with chronic granulomatous disease (CGD) eventually failing azole-echinocandin combination therapy were investigated. The first two isolates (1 and 2) were susceptible to antifungal azoles, but increased itraconazole, voriconazole and pos...

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Autores principales: Maiken Cavling Arendrup, Eleftheria Mavridou, Klaus Leth Mortensen, Eveline Snelders, Niels Frimodt-Møller, Humara Khan, Willem J G Melchers, Paul E Verweij
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/34a422c5b83d4335a86546298a249e3f
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