R-spondins are BMP receptor antagonists in Xenopus early embryonic development

R-spondins are BMP receptor antagonists in Xenopus early embryonic development

R-spondins are known modulators of Wnt signaling. Here, the authors demonstrate that R-spondins function in Xenopus embryonic development as BMP antagonists by targeting BMP receptor 1A for degradation.

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Autores principales: Hyeyoon Lee, Carina Seidl, Rui Sun, Andrey Glinka, Christof Niehrs
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/34a5e992ac2c477285dd80f3a3141eee
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spelling oai:doaj.org-article:34a5e992ac2c477285dd80f3a3141eee2021-12-02T15:37:15ZR-spondins are BMP receptor antagonists in Xenopus early embryonic development10.1038/s41467-020-19373-w2041-1723https://doaj.org/article/34a5e992ac2c477285dd80f3a3141eee2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19373-whttps://doaj.org/toc/2041-1723R-spondins are known modulators of Wnt signaling. Here, the authors demonstrate that R-spondins function in Xenopus embryonic development as BMP antagonists by targeting BMP receptor 1A for degradation.Hyeyoon LeeCarina SeidlRui SunAndrey GlinkaChristof NiehrsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hyeyoon Lee
Carina Seidl
Rui Sun
Andrey Glinka
Christof Niehrs
R-spondins are BMP receptor antagonists in Xenopus early embryonic development
description R-spondins are known modulators of Wnt signaling. Here, the authors demonstrate that R-spondins function in Xenopus embryonic development as BMP antagonists by targeting BMP receptor 1A for degradation.
format article
author Hyeyoon Lee
Carina Seidl
Rui Sun
Andrey Glinka
Christof Niehrs
author_facet Hyeyoon Lee
Carina Seidl
Rui Sun
Andrey Glinka
Christof Niehrs
author_sort Hyeyoon Lee
title R-spondins are BMP receptor antagonists in Xenopus early embryonic development
title_short R-spondins are BMP receptor antagonists in Xenopus early embryonic development
title_full R-spondins are BMP receptor antagonists in Xenopus early embryonic development
title_fullStr R-spondins are BMP receptor antagonists in Xenopus early embryonic development
title_full_unstemmed R-spondins are BMP receptor antagonists in Xenopus early embryonic development
title_sort r-spondins are bmp receptor antagonists in xenopus early embryonic development
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/34a5e992ac2c477285dd80f3a3141eee
work_keys_str_mv AT hyeyoonlee rspondinsarebmpreceptorantagonistsinxenopusearlyembryonicdevelopment
AT carinaseidl rspondinsarebmpreceptorantagonistsinxenopusearlyembryonicdevelopment
AT ruisun rspondinsarebmpreceptorantagonistsinxenopusearlyembryonicdevelopment
AT andreyglinka rspondinsarebmpreceptorantagonistsinxenopusearlyembryonicdevelopment
AT christofniehrs rspondinsarebmpreceptorantagonistsinxenopusearlyembryonicdevelopment
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