A meta-analysis of data associating DRD4 gene polymorphisms with schizophrenia

Feng-ling Xu, Xue Wu, Jing-jing Zhang, Bao-jie Wang, Jun Yao Department of Forensic, Genetic and Biology Medicine, School of Forensic Medicine, China Medical University, Shenyang, China Abstract: To explore the association between DRD4 polymorphisms and schizophrenia risk, a meta-analysis was carr...

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Autores principales:	Xu F, Wu X, Zhang J, Wang B, Yao J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	DRD4 schizophrenia meta-analysis polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/34a95987f879407c93fad2a5442ff931
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spelling	oai:doaj.org-article:34a95987f879407c93fad2a5442ff9312021-12-02T03:01:48ZA meta-analysis of data associating DRD4 gene polymorphisms with schizophrenia1178-2021https://doaj.org/article/34a95987f879407c93fad2a5442ff9312018-01-01T00:00:00Zhttps://www.dovepress.com/a-meta-analysis-of-data-associating-drd4-gene-polymorphisms-with-schiz-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Feng-ling Xu, Xue Wu, Jing-jing Zhang, Bao-jie Wang, Jun Yao Department of Forensic, Genetic and Biology Medicine, School of Forensic Medicine, China Medical University, Shenyang, China Abstract: To explore the association between DRD4 polymorphisms and schizophrenia risk, a meta-analysis was carried out with 41 case–control articles. Specifically, we included 28 articles (5,735 cases and 5,278 controls) that pertained to the 48 bp variable number tandem repeat (VNTR) polymorphism, nine articles (1,517 cases and 1,746 controls) that corresponded to the 12 bp tandem repeat (TR), six articles (1,912 cases and 1,836 controls) that addressed the 120 bp TR, 10 articles (2,927 cases and 2,938 controls) that entailed the −521 C>T polymorphism, six articles (1,735 cases and 1,724 controls) that pertained to the −616 C>G polymorphism, and four articles (1,191 cases and 1,215 controls) that involved the −376 C>T polymorphism. Pooled analysis, subgroup analysis, and sensitivity analysis were performed, and the data were visualized by means of forest and funnel plots. Results of pooled analysis indicated that the -521 CC variant (Pz=0.009, odds ratio [OR] =1.218, 95% confidence interval [CI] =1.050–1.413) and genotype L/L (ie, long allele) of the 120 bp TR were risk factors of schizophrenia (Pz=0.004, OR =1.275, 95% CI =1.081–1.504). The 48 bp VNTR, the 12 bp TR, the −616 C>G polymorphism, and the −376 C>T polymorphism were not associated with schizophrenia. Additional research is warranted to explore the association between polymorphisms of DRD4 and schizophrenia risk. Keywords: DRD4, schizophrenia, meta-analysis, polymorphismXu FWu XZhang JWang BYao JDove Medical PressarticleDRD4schizophreniameta-analysispolymorphismNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 153-164 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	DRD4 schizophrenia meta-analysis polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	DRD4 schizophrenia meta-analysis polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xu F Wu X Zhang J Wang B Yao J A meta-analysis of data associating DRD4 gene polymorphisms with schizophrenia
description	Feng-ling Xu, Xue Wu, Jing-jing Zhang, Bao-jie Wang, Jun Yao Department of Forensic, Genetic and Biology Medicine, School of Forensic Medicine, China Medical University, Shenyang, China Abstract: To explore the association between DRD4 polymorphisms and schizophrenia risk, a meta-analysis was carried out with 41 case–control articles. Specifically, we included 28 articles (5,735 cases and 5,278 controls) that pertained to the 48 bp variable number tandem repeat (VNTR) polymorphism, nine articles (1,517 cases and 1,746 controls) that corresponded to the 12 bp tandem repeat (TR), six articles (1,912 cases and 1,836 controls) that addressed the 120 bp TR, 10 articles (2,927 cases and 2,938 controls) that entailed the −521 C>T polymorphism, six articles (1,735 cases and 1,724 controls) that pertained to the −616 C>G polymorphism, and four articles (1,191 cases and 1,215 controls) that involved the −376 C>T polymorphism. Pooled analysis, subgroup analysis, and sensitivity analysis were performed, and the data were visualized by means of forest and funnel plots. Results of pooled analysis indicated that the -521 CC variant (Pz=0.009, odds ratio [OR] =1.218, 95% confidence interval [CI] =1.050–1.413) and genotype L/L (ie, long allele) of the 120 bp TR were risk factors of schizophrenia (Pz=0.004, OR =1.275, 95% CI =1.081–1.504). The 48 bp VNTR, the 12 bp TR, the −616 C>G polymorphism, and the −376 C>T polymorphism were not associated with schizophrenia. Additional research is warranted to explore the association between polymorphisms of DRD4 and schizophrenia risk. Keywords: DRD4, schizophrenia, meta-analysis, polymorphism
format	article
author	Xu F Wu X Zhang J Wang B Yao J
author_facet	Xu F Wu X Zhang J Wang B Yao J
author_sort	Xu F
title	A meta-analysis of data associating DRD4 gene polymorphisms with schizophrenia
title_short	A meta-analysis of data associating DRD4 gene polymorphisms with schizophrenia
title_full	A meta-analysis of data associating DRD4 gene polymorphisms with schizophrenia
title_fullStr	A meta-analysis of data associating DRD4 gene polymorphisms with schizophrenia
title_full_unstemmed	A meta-analysis of data associating DRD4 gene polymorphisms with schizophrenia
title_sort	meta-analysis of data associating drd4 gene polymorphisms with schizophrenia
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/34a95987f879407c93fad2a5442ff931
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A meta-analysis of data associating DRD4 gene polymorphisms with schizophrenia

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