Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure

There is a lack of human models to study vocal fold epithelia making it difficult to provide therapies for vocal fold disease. Here, the authors generate a human-based model of vocal fold mucosa that mimics in utero development and shows inflammation on exposure to cigarette smoke abstract.

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Autores principales: Vlasta Lungova, Xia Chen, Ziyue Wang, Christina Kendziorski, Susan L. Thibeault
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/34aff485983d44beb8daab94f4462674
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spelling oai:doaj.org-article:34aff485983d44beb8daab94f44626742021-12-02T17:31:22ZHuman induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure10.1038/s41467-019-12069-w2041-1723https://doaj.org/article/34aff485983d44beb8daab94f44626742019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12069-whttps://doaj.org/toc/2041-1723There is a lack of human models to study vocal fold epithelia making it difficult to provide therapies for vocal fold disease. Here, the authors generate a human-based model of vocal fold mucosa that mimics in utero development and shows inflammation on exposure to cigarette smoke abstract.Vlasta LungovaXia ChenZiyue WangChristina KendziorskiSusan L. ThibeaultNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Vlasta Lungova
Xia Chen
Ziyue Wang
Christina Kendziorski
Susan L. Thibeault
Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
description There is a lack of human models to study vocal fold epithelia making it difficult to provide therapies for vocal fold disease. Here, the authors generate a human-based model of vocal fold mucosa that mimics in utero development and shows inflammation on exposure to cigarette smoke abstract.
format article
author Vlasta Lungova
Xia Chen
Ziyue Wang
Christina Kendziorski
Susan L. Thibeault
author_facet Vlasta Lungova
Xia Chen
Ziyue Wang
Christina Kendziorski
Susan L. Thibeault
author_sort Vlasta Lungova
title Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
title_short Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
title_full Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
title_fullStr Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
title_full_unstemmed Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
title_sort human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/34aff485983d44beb8daab94f4462674
work_keys_str_mv AT vlastalungova humaninducedpluripotentstemcellderivedvocalfoldmucosamimicsdevelopmentandresponsestosmokeexposure
AT xiachen humaninducedpluripotentstemcellderivedvocalfoldmucosamimicsdevelopmentandresponsestosmokeexposure
AT ziyuewang humaninducedpluripotentstemcellderivedvocalfoldmucosamimicsdevelopmentandresponsestosmokeexposure
AT christinakendziorski humaninducedpluripotentstemcellderivedvocalfoldmucosamimicsdevelopmentandresponsestosmokeexposure
AT susanlthibeault humaninducedpluripotentstemcellderivedvocalfoldmucosamimicsdevelopmentandresponsestosmokeexposure
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