Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?

The activation of microglia, the inflammatory cells of the central nervous system (CNS), has been linked to the pathogenesis of Alzheimer’s disease and other neurodegenerative diseases. How microglia sense the changing brain environment, in order to respond appropriately, is still being elucidated....

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Autores principales:	Lucrezia Bruno, Simge Karagil, Almas Mahmood, Ahmed Elbediwy, Michael Stolinski, Francesca E. Mackenzie
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Hippo YAP MST1 mechanotransduction mechanosensing microglia Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/34b2987a2de140e5853920b925d2b122
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id	oai:doaj.org-article:34b2987a2de140e5853920b925d2b122
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spelling	oai:doaj.org-article:34b2987a2de140e5853920b925d2b1222021-11-25T17:11:57ZMechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?10.3390/cells101131442073-4409https://doaj.org/article/34b2987a2de140e5853920b925d2b1222021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3144https://doaj.org/toc/2073-4409The activation of microglia, the inflammatory cells of the central nervous system (CNS), has been linked to the pathogenesis of Alzheimer’s disease and other neurodegenerative diseases. How microglia sense the changing brain environment, in order to respond appropriately, is still being elucidated. Microglia are able to sense and respond to the mechanical properties of their microenvironment, and the physical and molecular pathways underlying this mechanosensing/mechanotransduction in microglia have recently been investigated. The Hippo pathway functions through mechanosensing and subsequent protein kinase cascades, and is critical for neuronal development and many other cellular processes. In this review, we examine evidence for the potential involvement of Hippo pathway components specifically in microglia in the pathogenesis of Alzheimer’s disease. We suggest that the Hippo pathway is worth investigating as a mechanosensing pathway in microglia, and could be one potential therapeutic target pathway for preventing microglial-induced neurodegeneration in AD.Lucrezia BrunoSimge KaragilAlmas MahmoodAhmed ElbediwyMichael StolinskiFrancesca E. MackenzieMDPI AGarticleHippoYAPMST1mechanotransductionmechanosensingmicrogliaBiology (General)QH301-705.5ENCells, Vol 10, Iss 3144, p 3144 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hippo YAP MST1 mechanotransduction mechanosensing microglia Biology (General) QH301-705.5
spellingShingle	Hippo YAP MST1 mechanotransduction mechanosensing microglia Biology (General) QH301-705.5 Lucrezia Bruno Simge Karagil Almas Mahmood Ahmed Elbediwy Michael Stolinski Francesca E. Mackenzie Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?
description	The activation of microglia, the inflammatory cells of the central nervous system (CNS), has been linked to the pathogenesis of Alzheimer’s disease and other neurodegenerative diseases. How microglia sense the changing brain environment, in order to respond appropriately, is still being elucidated. Microglia are able to sense and respond to the mechanical properties of their microenvironment, and the physical and molecular pathways underlying this mechanosensing/mechanotransduction in microglia have recently been investigated. The Hippo pathway functions through mechanosensing and subsequent protein kinase cascades, and is critical for neuronal development and many other cellular processes. In this review, we examine evidence for the potential involvement of Hippo pathway components specifically in microglia in the pathogenesis of Alzheimer’s disease. We suggest that the Hippo pathway is worth investigating as a mechanosensing pathway in microglia, and could be one potential therapeutic target pathway for preventing microglial-induced neurodegeneration in AD.
format	article
author	Lucrezia Bruno Simge Karagil Almas Mahmood Ahmed Elbediwy Michael Stolinski Francesca E. Mackenzie
author_facet	Lucrezia Bruno Simge Karagil Almas Mahmood Ahmed Elbediwy Michael Stolinski Francesca E. Mackenzie
author_sort	Lucrezia Bruno
title	Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?
title_short	Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?
title_full	Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?
title_fullStr	Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?
title_full_unstemmed	Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?
title_sort	mechanosensing and the hippo pathway in microglia: a potential link to alzheimer’s disease pathogenesis?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/34b2987a2de140e5853920b925d2b122
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Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?

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