Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles

Host kinases facilitate Plasmodium liver stage (LS) infection, but systematic accounting of important players is lacking. Here, the authors use a computational approach and kinase activity profiles to identify host kinase regulators of LS infection and drugs that could eliminate parasite burden.

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Autores principales:	Nadia Arang, Heather S. Kain, Elizabeth K. Glennon, Thomas Bello, Denali R. Dudgeon, Emily N. F. Walter, Taranjit S. Gujral, Alexis Kaushansky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/34b30dc350304d7da86e97eaeab203a7
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spelling	oai:doaj.org-article:34b30dc350304d7da86e97eaeab203a72021-12-02T17:06:19ZIdentifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles10.1038/s41467-017-01345-22041-1723https://doaj.org/article/34b30dc350304d7da86e97eaeab203a72017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01345-2https://doaj.org/toc/2041-1723Host kinases facilitate Plasmodium liver stage (LS) infection, but systematic accounting of important players is lacking. Here, the authors use a computational approach and kinase activity profiles to identify host kinase regulators of LS infection and drugs that could eliminate parasite burden.Nadia ArangHeather S. KainElizabeth K. GlennonThomas BelloDenali R. DudgeonEmily N. F. WalterTaranjit S. GujralAlexis KaushanskyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nadia Arang Heather S. Kain Elizabeth K. Glennon Thomas Bello Denali R. Dudgeon Emily N. F. Walter Taranjit S. Gujral Alexis Kaushansky Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles
description	Host kinases facilitate Plasmodium liver stage (LS) infection, but systematic accounting of important players is lacking. Here, the authors use a computational approach and kinase activity profiles to identify host kinase regulators of LS infection and drugs that could eliminate parasite burden.
format	article
author	Nadia Arang Heather S. Kain Elizabeth K. Glennon Thomas Bello Denali R. Dudgeon Emily N. F. Walter Taranjit S. Gujral Alexis Kaushansky
author_facet	Nadia Arang Heather S. Kain Elizabeth K. Glennon Thomas Bello Denali R. Dudgeon Emily N. F. Walter Taranjit S. Gujral Alexis Kaushansky
author_sort	Nadia Arang
title	Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles
title_short	Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles
title_full	Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles
title_fullStr	Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles
title_full_unstemmed	Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles
title_sort	identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/34b30dc350304d7da86e97eaeab203a7
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Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles

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