Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy

Abstract Glutamic acid decarboxylase 65 antibodies (anti-GAD65) have been found in patients with late-onset chronic temporal lobe epilepsy (TLE). No prior neuroimaging studies have addressed how they affect hippocampal volume and shape and how they relate to cognitive abnormalities. We aimed to inve...

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Autores principales:	Estefanía Conde-Blanco, Saül Pascual-Diaz, Mar Carreño, Emma Muñoz-Moreno, José Carlos Pariente, Teresa Boget, Isabel Manzanares, Antonio Donaire, María Centeno, Francesc Graus, Nuria Bargalló
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34ba8eee17874fb7865f98b1bf935d26
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spelling	oai:doaj.org-article:34ba8eee17874fb7865f98b1bf935d262021-12-02T15:55:18ZVolumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy10.1038/s41598-021-89010-z2045-2322https://doaj.org/article/34ba8eee17874fb7865f98b1bf935d262021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89010-zhttps://doaj.org/toc/2045-2322Abstract Glutamic acid decarboxylase 65 antibodies (anti-GAD65) have been found in patients with late-onset chronic temporal lobe epilepsy (TLE). No prior neuroimaging studies have addressed how they affect hippocampal volume and shape and how they relate to cognitive abnormalities. We aimed to investigate both brain structure and function in patients with isolated TLE and high anti-GAD65 levels (RIA ≥ 2000 U/ml) compared to 8 non-immune mesial TLE (niTLE) and 8 healthy controls (HC). Hippocampal subfield volume properties were correlated with the duration of the disease and cognitive test scores. The affected hippocampus of GAD-TLE patients showed no volume changes to matched HC whereas niTLE volumes were significantly smaller. Epilepsy duration in GAD-TLE patients correlated negatively with volumes in the presubiculum, subiculum, CA1, CA2–3, CA4, molecular layer and granule cell-molecular layer of the dentate nucleus. We found differences by advanced vertex-wise shape analysis in the anterior hippocampus of the left GAD-TLE compared to HC whereas left niTLE showed bilateral posterior hippocampus deformation. Verbal deficits were similar in GAD-TLE and niTLE but did not correlate to volume changes. These data might suggest a distinct expression of hippocampal structural and functional abnormalities based on the immune response.Estefanía Conde-BlancoSaül Pascual-DiazMar CarreñoEmma Muñoz-MorenoJosé Carlos ParienteTeresa BogetIsabel ManzanaresAntonio DonaireMaría CentenoFrancesc GrausNuria BargallóNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Estefanía Conde-Blanco Saül Pascual-Diaz Mar Carreño Emma Muñoz-Moreno José Carlos Pariente Teresa Boget Isabel Manzanares Antonio Donaire María Centeno Francesc Graus Nuria Bargalló Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy
description	Abstract Glutamic acid decarboxylase 65 antibodies (anti-GAD65) have been found in patients with late-onset chronic temporal lobe epilepsy (TLE). No prior neuroimaging studies have addressed how they affect hippocampal volume and shape and how they relate to cognitive abnormalities. We aimed to investigate both brain structure and function in patients with isolated TLE and high anti-GAD65 levels (RIA ≥ 2000 U/ml) compared to 8 non-immune mesial TLE (niTLE) and 8 healthy controls (HC). Hippocampal subfield volume properties were correlated with the duration of the disease and cognitive test scores. The affected hippocampus of GAD-TLE patients showed no volume changes to matched HC whereas niTLE volumes were significantly smaller. Epilepsy duration in GAD-TLE patients correlated negatively with volumes in the presubiculum, subiculum, CA1, CA2–3, CA4, molecular layer and granule cell-molecular layer of the dentate nucleus. We found differences by advanced vertex-wise shape analysis in the anterior hippocampus of the left GAD-TLE compared to HC whereas left niTLE showed bilateral posterior hippocampus deformation. Verbal deficits were similar in GAD-TLE and niTLE but did not correlate to volume changes. These data might suggest a distinct expression of hippocampal structural and functional abnormalities based on the immune response.
format	article
author	Estefanía Conde-Blanco Saül Pascual-Diaz Mar Carreño Emma Muñoz-Moreno José Carlos Pariente Teresa Boget Isabel Manzanares Antonio Donaire María Centeno Francesc Graus Nuria Bargalló
author_facet	Estefanía Conde-Blanco Saül Pascual-Diaz Mar Carreño Emma Muñoz-Moreno José Carlos Pariente Teresa Boget Isabel Manzanares Antonio Donaire María Centeno Francesc Graus Nuria Bargalló
author_sort	Estefanía Conde-Blanco
title	Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy
title_short	Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy
title_full	Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy
title_fullStr	Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy
title_full_unstemmed	Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy
title_sort	volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with gad65 antibodies compared with non-immune epilepsy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/34ba8eee17874fb7865f98b1bf935d26
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Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy

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