Polymer coated gold nanoshells for combinational photochemotherapy of pancreatic cancer with gemcitabine

Abstract Pancreatic cancer is one of the most lethal malignancies with limited therapeutic options and dismal prognosis. Gemcitabine is the front-line drug against pancreatic cancer however with limited improvement of therapeutic outcomes. In this study we envisaged the integration of GEM with gold...

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Autores principales:	Mina Emamzadeh, George Pasparakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34bd49c34d0e42a5939a788645c33ee5
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spelling	oai:doaj.org-article:34bd49c34d0e42a5939a788645c33ee52021-12-02T17:39:30ZPolymer coated gold nanoshells for combinational photochemotherapy of pancreatic cancer with gemcitabine10.1038/s41598-021-88909-x2045-2322https://doaj.org/article/34bd49c34d0e42a5939a788645c33ee52021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88909-xhttps://doaj.org/toc/2045-2322Abstract Pancreatic cancer is one of the most lethal malignancies with limited therapeutic options and dismal prognosis. Gemcitabine is the front-line drug against pancreatic cancer however with limited improvement of therapeutic outcomes. In this study we envisaged the integration of GEM with gold nanoshells which constitute an interesting class of nanomaterials with excellent photothermal conversion properties. Nanoshells were coated with thiol-capped poly(ethylene glycol) methacrylate polymers of different molecular weight via Au–S attachment. It was found that the molecular weight of the polymers affects the in vitro performance of the formulations; more importantly we demonstrate that the EC50 of nanoshell loaded GEM can be suppressed but fully restored and even improved upon laser irradiation. Our proposed nanoformulations outperformed the cytotoxicity of the parent drug and showed confined synergism under the tested in vitro conditions.Mina EmamzadehGeorge PasparakisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mina Emamzadeh George Pasparakis Polymer coated gold nanoshells for combinational photochemotherapy of pancreatic cancer with gemcitabine
description	Abstract Pancreatic cancer is one of the most lethal malignancies with limited therapeutic options and dismal prognosis. Gemcitabine is the front-line drug against pancreatic cancer however with limited improvement of therapeutic outcomes. In this study we envisaged the integration of GEM with gold nanoshells which constitute an interesting class of nanomaterials with excellent photothermal conversion properties. Nanoshells were coated with thiol-capped poly(ethylene glycol) methacrylate polymers of different molecular weight via Au–S attachment. It was found that the molecular weight of the polymers affects the in vitro performance of the formulations; more importantly we demonstrate that the EC50 of nanoshell loaded GEM can be suppressed but fully restored and even improved upon laser irradiation. Our proposed nanoformulations outperformed the cytotoxicity of the parent drug and showed confined synergism under the tested in vitro conditions.
format	article
author	Mina Emamzadeh George Pasparakis
author_facet	Mina Emamzadeh George Pasparakis
author_sort	Mina Emamzadeh
title	Polymer coated gold nanoshells for combinational photochemotherapy of pancreatic cancer with gemcitabine
title_short	Polymer coated gold nanoshells for combinational photochemotherapy of pancreatic cancer with gemcitabine
title_full	Polymer coated gold nanoshells for combinational photochemotherapy of pancreatic cancer with gemcitabine
title_fullStr	Polymer coated gold nanoshells for combinational photochemotherapy of pancreatic cancer with gemcitabine
title_full_unstemmed	Polymer coated gold nanoshells for combinational photochemotherapy of pancreatic cancer with gemcitabine
title_sort	polymer coated gold nanoshells for combinational photochemotherapy of pancreatic cancer with gemcitabine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/34bd49c34d0e42a5939a788645c33ee5
work_keys_str_mv	AT minaemamzadeh polymercoatedgoldnanoshellsforcombinationalphotochemotherapyofpancreaticcancerwithgemcitabine AT georgepasparakis polymercoatedgoldnanoshellsforcombinationalphotochemotherapyofpancreaticcancerwithgemcitabine
_version_	1718379815510212608

Polymer coated gold nanoshells for combinational photochemotherapy of pancreatic cancer with gemcitabine

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