Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia

Dysfunction of GABAergic neurons in the prefrontal cortex has been reported in schizophrenia. Here, the authors use the apomorphine-susceptible rat, which displays some schizophrenia-like behaviors, and show that interneurons in the medial prefrontal cortex are hypomyelinated, which may contribute t...

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Autores principales:	Dorien A. Maas, Vivian D. Eijsink, Marcia Spoelder, Josephus A. van Hulten, Peter De Weerd, Judith R. Homberg, Astrid Vallès, Brahim Nait-Oumesmar, Gerard J. M. Martens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/34c57aa0fb3a4c8899725ee021846a0b
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spelling	oai:doaj.org-article:34c57aa0fb3a4c8899725ee021846a0b2021-12-02T14:35:46ZInterneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia10.1038/s41467-020-16218-42041-1723https://doaj.org/article/34c57aa0fb3a4c8899725ee021846a0b2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16218-4https://doaj.org/toc/2041-1723Dysfunction of GABAergic neurons in the prefrontal cortex has been reported in schizophrenia. Here, the authors use the apomorphine-susceptible rat, which displays some schizophrenia-like behaviors, and show that interneurons in the medial prefrontal cortex are hypomyelinated, which may contribute to this behavioral phenotype.Dorien A. MaasVivian D. EijsinkMarcia SpoelderJosephus A. van HultenPeter De WeerdJudith R. HombergAstrid VallèsBrahim Nait-OumesmarGerard J. M. MartensNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dorien A. Maas Vivian D. Eijsink Marcia Spoelder Josephus A. van Hulten Peter De Weerd Judith R. Homberg Astrid Vallès Brahim Nait-Oumesmar Gerard J. M. Martens Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia
description	Dysfunction of GABAergic neurons in the prefrontal cortex has been reported in schizophrenia. Here, the authors use the apomorphine-susceptible rat, which displays some schizophrenia-like behaviors, and show that interneurons in the medial prefrontal cortex are hypomyelinated, which may contribute to this behavioral phenotype.
format	article
author	Dorien A. Maas Vivian D. Eijsink Marcia Spoelder Josephus A. van Hulten Peter De Weerd Judith R. Homberg Astrid Vallès Brahim Nait-Oumesmar Gerard J. M. Martens
author_facet	Dorien A. Maas Vivian D. Eijsink Marcia Spoelder Josephus A. van Hulten Peter De Weerd Judith R. Homberg Astrid Vallès Brahim Nait-Oumesmar Gerard J. M. Martens
author_sort	Dorien A. Maas
title	Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia
title_short	Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia
title_full	Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia
title_fullStr	Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia
title_full_unstemmed	Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia
title_sort	interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/34c57aa0fb3a4c8899725ee021846a0b
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Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia

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