The Role of Endothelium in COVID-19

The 2019 novel coronavirus, known as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19), is causing a global pandemic. The virus primarily affects the upper and lower respiratory tracts and raises the risk of a variety of non-pulmonary consequences, t...

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Autores principales:	Mihaela Ionescu, Anca Pantea Stoian, Manfredi Rizzo, Dragos Serban, Domenico Nuzzo, Laura Mazilu, Andra Iulia Suceveanu, Ana Maria Dascalu, Irinel Raluca Parepa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	endothelium SARS-CoV-2 COVID-19 pathogenesis complications Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/34c75f5d43574dc1910d18ec5aa9026d
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id	oai:doaj.org-article:34c75f5d43574dc1910d18ec5aa9026d
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spelling	oai:doaj.org-article:34c75f5d43574dc1910d18ec5aa9026d2021-11-11T17:20:07ZThe Role of Endothelium in COVID-1910.3390/ijms2221119201422-00671661-6596https://doaj.org/article/34c75f5d43574dc1910d18ec5aa9026d2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11920https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The 2019 novel coronavirus, known as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19), is causing a global pandemic. The virus primarily affects the upper and lower respiratory tracts and raises the risk of a variety of non-pulmonary consequences, the most severe and possibly fatal of which are cardiovascular problems. Data show that almost one-third of the patients with a moderate or severe form of COVID-19 had preexisting cardiovascular comorbidities such as diabetes mellitus, obesity, hypertension, heart failure, or coronary artery disease. SARS-CoV2 causes hyper inflammation, hypoxia, apoptosis, and a renin–angiotensin system imbalance in a variety of cell types, primarily endothelial cells. Profound endothelial dysfunction associated with COVID-19 can be the cause of impaired organ perfusion that may generate acute myocardial injury, renal failure, and a procoagulant state resulting in thromboembolic events. We discuss the most recent results on the involvement of endothelial dysfunction in the pathogenesis of COVID-19 in patients with cardiometabolic diseases in this review. We also provide insights on treatments that may reduce the severity of this viral infection.Mihaela IonescuAnca Pantea StoianManfredi RizzoDragos SerbanDomenico NuzzoLaura MaziluAndra Iulia SuceveanuAna Maria DascaluIrinel Raluca ParepaMDPI AGarticleendotheliumSARS-CoV-2COVID-19pathogenesiscomplicationsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11920, p 11920 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endothelium SARS-CoV-2 COVID-19 pathogenesis complications Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	endothelium SARS-CoV-2 COVID-19 pathogenesis complications Biology (General) QH301-705.5 Chemistry QD1-999 Mihaela Ionescu Anca Pantea Stoian Manfredi Rizzo Dragos Serban Domenico Nuzzo Laura Mazilu Andra Iulia Suceveanu Ana Maria Dascalu Irinel Raluca Parepa The Role of Endothelium in COVID-19
description	The 2019 novel coronavirus, known as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19), is causing a global pandemic. The virus primarily affects the upper and lower respiratory tracts and raises the risk of a variety of non-pulmonary consequences, the most severe and possibly fatal of which are cardiovascular problems. Data show that almost one-third of the patients with a moderate or severe form of COVID-19 had preexisting cardiovascular comorbidities such as diabetes mellitus, obesity, hypertension, heart failure, or coronary artery disease. SARS-CoV2 causes hyper inflammation, hypoxia, apoptosis, and a renin–angiotensin system imbalance in a variety of cell types, primarily endothelial cells. Profound endothelial dysfunction associated with COVID-19 can be the cause of impaired organ perfusion that may generate acute myocardial injury, renal failure, and a procoagulant state resulting in thromboembolic events. We discuss the most recent results on the involvement of endothelial dysfunction in the pathogenesis of COVID-19 in patients with cardiometabolic diseases in this review. We also provide insights on treatments that may reduce the severity of this viral infection.
format	article
author	Mihaela Ionescu Anca Pantea Stoian Manfredi Rizzo Dragos Serban Domenico Nuzzo Laura Mazilu Andra Iulia Suceveanu Ana Maria Dascalu Irinel Raluca Parepa
author_facet	Mihaela Ionescu Anca Pantea Stoian Manfredi Rizzo Dragos Serban Domenico Nuzzo Laura Mazilu Andra Iulia Suceveanu Ana Maria Dascalu Irinel Raluca Parepa
author_sort	Mihaela Ionescu
title	The Role of Endothelium in COVID-19
title_short	The Role of Endothelium in COVID-19
title_full	The Role of Endothelium in COVID-19
title_fullStr	The Role of Endothelium in COVID-19
title_full_unstemmed	The Role of Endothelium in COVID-19
title_sort	role of endothelium in covid-19
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/34c75f5d43574dc1910d18ec5aa9026d
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The Role of Endothelium in COVID-19

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