Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia

Małgorzata Urban-Kowalczyk,1 Janusz Śmigielski,2 Dominik Strzelecki1 1Department of Affective and Psychotic Disorders, 2Department of Geriatrics, Healthy Aging Research Centre (HARC), Medical University of Lodz, Lodz, Poland Objectives: Links between endorphins and dopaminergic t...

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Autores principales:	Urban-Kowalczyk M, Śmigielski J, Strzelecki D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	schizophrenia negative symptoms neuroleptics β-endorpin calcitonin gene-related peptide Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/34ce0cb45fc54d6d9f048bffc9446471
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spelling	oai:doaj.org-article:34ce0cb45fc54d6d9f048bffc94464712021-12-02T02:18:49ZComparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia1178-2021https://doaj.org/article/34ce0cb45fc54d6d9f048bffc94464712016-04-01T00:00:00Zhttps://www.dovepress.com/comparison-of-beta-endorphin-and-cgrp-levels-before-and-after-treatmen-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Małgorzata Urban-Kowalczyk,1 Janusz Śmigielski,2 Dominik Strzelecki1 1Department of Affective and Psychotic Disorders, 2Department of Geriatrics, Healthy Aging Research Centre (HARC), Medical University of Lodz, Lodz, Poland Objectives: Links between endorphins and dopaminergic transmission have not been fully explored in schizophrenia. Both endorphins excess and deficiency were postulated. CGRP is probably involved in dopaminergic transmission. The aim of this study was the evaluation of beta-endorphin (BE) and CGRP blood concentrations before and after treatment of severe schizophrenia. Methods: Seventy patients treated with various antipsychotics, with severe symptoms of schizophrenia (51 with positive symptoms, 19 with negative symptoms), 15 first-degree relatives, and 44 healthy controls were included in the study. BE and CGRP blood concentrations were measured during patients severe schizophrenia and in their stable mental state after treatment. The results were compared with relatives and controls. Results: BE and CGRP concentrations in patients with negative symptoms were higher than in relatives and in controls. BE levels in patients with positive symptoms were lower than in patients with negative symptoms (P<0.0000) and controls (P<0.0006). No significant changes in CGRP concentration were found in patient samples. CGRP levels in these samples were independent of treatment, but they were significantly higher than in relatives and controls. After the treatment, BE level decreased in patients with negative symptoms (P<0.0001) and increased in patients with positive symptoms (P<0.0000). No differences in BE concentration between patients in stable mental state, their relatives, and controls were found. Conclusion: Effective antipsychotic treatment results in “normalization” of BE level. Specific changes in BE concentration could be involved in dopaminergic transmission and related to some symptoms of schizophrenia. Keywords: schizophrenia, negative symptoms, neuroleptics, β-endorphin, CGRPUrban-Kowalczyk MŚmigielski JStrzelecki DDove Medical Pressarticleschizophrenianegative symptomsneurolepticsβ-endorpincalcitonin gene-related peptideNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 863-868 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia negative symptoms neuroleptics β-endorpin calcitonin gene-related peptide Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	schizophrenia negative symptoms neuroleptics β-endorpin calcitonin gene-related peptide Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Urban-Kowalczyk M Śmigielski J Strzelecki D Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
description	Małgorzata Urban-Kowalczyk,1 Janusz Śmigielski,2 Dominik Strzelecki1 1Department of Affective and Psychotic Disorders, 2Department of Geriatrics, Healthy Aging Research Centre (HARC), Medical University of Lodz, Lodz, Poland Objectives: Links between endorphins and dopaminergic transmission have not been fully explored in schizophrenia. Both endorphins excess and deficiency were postulated. CGRP is probably involved in dopaminergic transmission. The aim of this study was the evaluation of beta-endorphin (BE) and CGRP blood concentrations before and after treatment of severe schizophrenia. Methods: Seventy patients treated with various antipsychotics, with severe symptoms of schizophrenia (51 with positive symptoms, 19 with negative symptoms), 15 first-degree relatives, and 44 healthy controls were included in the study. BE and CGRP blood concentrations were measured during patients severe schizophrenia and in their stable mental state after treatment. The results were compared with relatives and controls. Results: BE and CGRP concentrations in patients with negative symptoms were higher than in relatives and in controls. BE levels in patients with positive symptoms were lower than in patients with negative symptoms (P<0.0000) and controls (P<0.0006). No significant changes in CGRP concentration were found in patient samples. CGRP levels in these samples were independent of treatment, but they were significantly higher than in relatives and controls. After the treatment, BE level decreased in patients with negative symptoms (P<0.0001) and increased in patients with positive symptoms (P<0.0000). No differences in BE concentration between patients in stable mental state, their relatives, and controls were found. Conclusion: Effective antipsychotic treatment results in “normalization” of BE level. Specific changes in BE concentration could be involved in dopaminergic transmission and related to some symptoms of schizophrenia. Keywords: schizophrenia, negative symptoms, neuroleptics, β-endorphin, CGRP
format	article
author	Urban-Kowalczyk M Śmigielski J Strzelecki D
author_facet	Urban-Kowalczyk M Śmigielski J Strzelecki D
author_sort	Urban-Kowalczyk M
title	Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
title_short	Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
title_full	Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
title_fullStr	Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
title_full_unstemmed	Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
title_sort	comparison of beta-endorphin and cgrp levels before and after treatment for severe schizophrenia
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/34ce0cb45fc54d6d9f048bffc9446471
work_keys_str_mv	AT urbankowalczykm comparisonofbetaendorphinandcgrplevelsbeforeandaftertreatmentforsevereschizophrenia AT smigielskij comparisonofbetaendorphinandcgrplevelsbeforeandaftertreatmentforsevereschizophrenia AT strzeleckid comparisonofbetaendorphinandcgrplevelsbeforeandaftertreatmentforsevereschizophrenia
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Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia

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