Fiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota

Abstract The gut microbiota of individuals are dominated by different fiber-utilizing bacteria, which ferment dietary fiber into short chain fatty acids (SCFAs) known to be important for human health. Here, we show that the dominance of Prevotella versus Bacteroides in fecal innocula, identified int...

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Autores principales:	Tingting Chen, Wenmin Long, Chenhong Zhang, Shuang Liu, Liping Zhao, Bruce R. Hamaker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34ce23b16a7f4192a3175f5fa4993f4e
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spelling	oai:doaj.org-article:34ce23b16a7f4192a3175f5fa4993f4e2021-12-02T16:06:47ZFiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota10.1038/s41598-017-02995-42045-2322https://doaj.org/article/34ce23b16a7f4192a3175f5fa4993f4e2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02995-4https://doaj.org/toc/2045-2322Abstract The gut microbiota of individuals are dominated by different fiber-utilizing bacteria, which ferment dietary fiber into short chain fatty acids (SCFAs) known to be important for human health. Here, we show that the dominance of Prevotella versus Bacteroides in fecal innocula, identified into two different enterotypes, differentially impacts in vitro fermentation profiles of SCFAs from fibers with different chemical structures. In a microbiome of the Prevotella enterotype, fructooligosaccharides, and sorghum and corn arabinoxylans significantly promoted one single Prevotella OTU with equally high production of total SCFAs with propionate as the major product. Conversely, in the Bacteroides-dominated microbiota, the three fibers enriched different OTUs leading to different levels and ratios of SCFAs. This is the first report showing how individual differences in two enterotypes cause distinctly different responses to dietary fiber. Microbiota dominated by different fiber-utilizing bacteria may impact host health by way of producing different amounts and profiles of SCFAs from the same carbohydrate substrates.Tingting ChenWenmin LongChenhong ZhangShuang LiuLiping ZhaoBruce R. HamakerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tingting Chen Wenmin Long Chenhong Zhang Shuang Liu Liping Zhao Bruce R. Hamaker Fiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota
description	Abstract The gut microbiota of individuals are dominated by different fiber-utilizing bacteria, which ferment dietary fiber into short chain fatty acids (SCFAs) known to be important for human health. Here, we show that the dominance of Prevotella versus Bacteroides in fecal innocula, identified into two different enterotypes, differentially impacts in vitro fermentation profiles of SCFAs from fibers with different chemical structures. In a microbiome of the Prevotella enterotype, fructooligosaccharides, and sorghum and corn arabinoxylans significantly promoted one single Prevotella OTU with equally high production of total SCFAs with propionate as the major product. Conversely, in the Bacteroides-dominated microbiota, the three fibers enriched different OTUs leading to different levels and ratios of SCFAs. This is the first report showing how individual differences in two enterotypes cause distinctly different responses to dietary fiber. Microbiota dominated by different fiber-utilizing bacteria may impact host health by way of producing different amounts and profiles of SCFAs from the same carbohydrate substrates.
format	article
author	Tingting Chen Wenmin Long Chenhong Zhang Shuang Liu Liping Zhao Bruce R. Hamaker
author_facet	Tingting Chen Wenmin Long Chenhong Zhang Shuang Liu Liping Zhao Bruce R. Hamaker
author_sort	Tingting Chen
title	Fiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota
title_short	Fiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota
title_full	Fiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota
title_fullStr	Fiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota
title_full_unstemmed	Fiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota
title_sort	fiber-utilizing capacity varies in prevotella- versus bacteroides-dominated gut microbiota
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/34ce23b16a7f4192a3175f5fa4993f4e
work_keys_str_mv	AT tingtingchen fiberutilizingcapacityvariesinprevotellaversusbacteroidesdominatedgutmicrobiota AT wenminlong fiberutilizingcapacityvariesinprevotellaversusbacteroidesdominatedgutmicrobiota AT chenhongzhang fiberutilizingcapacityvariesinprevotellaversusbacteroidesdominatedgutmicrobiota AT shuangliu fiberutilizingcapacityvariesinprevotellaversusbacteroidesdominatedgutmicrobiota AT lipingzhao fiberutilizingcapacityvariesinprevotellaversusbacteroidesdominatedgutmicrobiota AT brucerhamaker fiberutilizingcapacityvariesinprevotellaversusbacteroidesdominatedgutmicrobiota
_version_	1718384835317202944

Fiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota

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