Treatment Approaches Based on Neuroscientific Data in Patients With Obsessive-Compulsive Disorder

Background: Obsessive-compulsive disorder (OCD) is a severe psychological disorder that can be very disabling. Recent increasing neuroscientific data about OCD has provided important evidence that has started to change our knowledge about treatment. This paper offers an applied perspective of neuros...

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Autores principales:	Mohammad Ansari Asl, Parviz Asgari, Seyedeh Zahra Bakhti
Formato:	article
Lenguaje:	EN
Publicado:	Shahid Beheshti University of Medical Sciences 2021
Materias:	obsessive-compulsive disorder ocd neuroscience neuro-treatment cstc loops neuroimaging Medicine R
Acceso en línea:	https://doaj.org/article/34cebe6f8b25497690a3cba55faebe83
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spelling	oai:doaj.org-article:34cebe6f8b25497690a3cba55faebe832021-11-16T10:51:17ZTreatment Approaches Based on Neuroscientific Data in Patients With Obsessive-Compulsive Disorder2383-18712383-209610.34172/icnj.2021.24https://doaj.org/article/34cebe6f8b25497690a3cba55faebe832021-07-01T00:00:00Zhttps://journals.sbmu.ac.ir/neuroscience/article/view/34725/27353https://doaj.org/toc/2383-1871https://doaj.org/toc/2383-2096Background: Obsessive-compulsive disorder (OCD) is a severe psychological disorder that can be very disabling. Recent increasing neuroscientific data about OCD has provided important evidence that has started to change our knowledge about treatment. This paper offers an applied perspective of neuroscience on diagnosis and treatment preparation for people with OCD disease. The main aim is to enhance clinician-researcher communication to promote the conversion of developments in neuroscience research into better treatment for patients with OCD. Methods: A PubMed search was performed using the keywords "obsessive-compulsive disorder", "neuroimaging methods", "neuroscience", and "neurological treatment". The search provided sufficient articles published in peer-reviewed journals from 1995 to 2021. The data were obtained from these various sources and were included in this review. Results: The advancement of neurotherapeutic techniques targeting the cortico-striatal-thalamo-cortical (CSTC) circuit is the subject of a circuit dysregulation system. Also, according to neuroimaging studies, reductions in D2 receptors (about -18%), GABAA receptors (-15%), and cingulate 5-HT1A receptors (-18%) in patients with OCD were reported compared with healthy controls. Conclusion: The result suggests that DA, 5-HT, and GABA have considerable roles in anxiety- and compulsion-related disorders such as OCD. For patients with OCD, these core neuroscience themes collectively guide formulation and clinical preparation.Mohammad Ansari AslParviz AsgariSeyedeh Zahra BakhtiShahid Beheshti University of Medical Sciencesarticleobsessive-compulsive disorderocdneuroscienceneuro-treatmentcstc loopsneuroimagingMedicineRENInternational Clinical Neuroscience Journal, Vol 8, Iss 3, Pp 107-117 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obsessive-compulsive disorder ocd neuroscience neuro-treatment cstc loops neuroimaging Medicine R
spellingShingle	obsessive-compulsive disorder ocd neuroscience neuro-treatment cstc loops neuroimaging Medicine R Mohammad Ansari Asl Parviz Asgari Seyedeh Zahra Bakhti Treatment Approaches Based on Neuroscientific Data in Patients With Obsessive-Compulsive Disorder
description	Background: Obsessive-compulsive disorder (OCD) is a severe psychological disorder that can be very disabling. Recent increasing neuroscientific data about OCD has provided important evidence that has started to change our knowledge about treatment. This paper offers an applied perspective of neuroscience on diagnosis and treatment preparation for people with OCD disease. The main aim is to enhance clinician-researcher communication to promote the conversion of developments in neuroscience research into better treatment for patients with OCD. Methods: A PubMed search was performed using the keywords "obsessive-compulsive disorder", "neuroimaging methods", "neuroscience", and "neurological treatment". The search provided sufficient articles published in peer-reviewed journals from 1995 to 2021. The data were obtained from these various sources and were included in this review. Results: The advancement of neurotherapeutic techniques targeting the cortico-striatal-thalamo-cortical (CSTC) circuit is the subject of a circuit dysregulation system. Also, according to neuroimaging studies, reductions in D2 receptors (about -18%), GABAA receptors (-15%), and cingulate 5-HT1A receptors (-18%) in patients with OCD were reported compared with healthy controls. Conclusion: The result suggests that DA, 5-HT, and GABA have considerable roles in anxiety- and compulsion-related disorders such as OCD. For patients with OCD, these core neuroscience themes collectively guide formulation and clinical preparation.
format	article
author	Mohammad Ansari Asl Parviz Asgari Seyedeh Zahra Bakhti
author_facet	Mohammad Ansari Asl Parviz Asgari Seyedeh Zahra Bakhti
author_sort	Mohammad Ansari Asl
title	Treatment Approaches Based on Neuroscientific Data in Patients With Obsessive-Compulsive Disorder
title_short	Treatment Approaches Based on Neuroscientific Data in Patients With Obsessive-Compulsive Disorder
title_full	Treatment Approaches Based on Neuroscientific Data in Patients With Obsessive-Compulsive Disorder
title_fullStr	Treatment Approaches Based on Neuroscientific Data in Patients With Obsessive-Compulsive Disorder
title_full_unstemmed	Treatment Approaches Based on Neuroscientific Data in Patients With Obsessive-Compulsive Disorder
title_sort	treatment approaches based on neuroscientific data in patients with obsessive-compulsive disorder
publisher	Shahid Beheshti University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/34cebe6f8b25497690a3cba55faebe83
work_keys_str_mv	AT mohammadansariasl treatmentapproachesbasedonneuroscientificdatainpatientswithobsessivecompulsivedisorder AT parvizasgari treatmentapproachesbasedonneuroscientificdatainpatientswithobsessivecompulsivedisorder AT seyedehzahrabakhti treatmentapproachesbasedonneuroscientificdatainpatientswithobsessivecompulsivedisorder
_version_	1718426536191721472

Treatment Approaches Based on Neuroscientific Data in Patients With Obsessive-Compulsive Disorder

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