Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood

Abstract Prenatal exposure to mercury, a known neurotoxic metal, is associated with lower cognitive performance during childhood. Disruption of fetal epigenetic programming could explain mercury’s neurodevelopmental effects. We screened for epigenome-wide methylation differences associated with mate...

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Autores principales:	Andres Cardenas, Sheryl L. Rifas-Shiman, Golareh Agha, Marie-France Hivert, Augusto A. Litonjua, Dawn L. DeMeo, Xihong Lin, Chitra J. Amarasiriwardena, Emily Oken, Matthew W. Gillman, Andrea A. Baccarelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34d1f356b4af4b6da9e45b49926acd1a
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spelling	oai:doaj.org-article:34d1f356b4af4b6da9e45b49926acd1a2021-12-02T15:06:00ZPersistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood10.1038/s41598-017-00384-52045-2322https://doaj.org/article/34d1f356b4af4b6da9e45b49926acd1a2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00384-5https://doaj.org/toc/2045-2322Abstract Prenatal exposure to mercury, a known neurotoxic metal, is associated with lower cognitive performance during childhood. Disruption of fetal epigenetic programming could explain mercury’s neurodevelopmental effects. We screened for epigenome-wide methylation differences associated with maternal prenatal blood mercury levels in 321 cord blood DNA samples and examined the persistence of these alterations during early (n = 75; 2.9–4.9 years) and mid-childhood (n = 291; 6.7–10.5 years). Among males, prenatal mercury levels were associated with lower regional cord blood DNA methylation at the Paraoxonase 1 gene (PON1) that persisted in early childhood and was attenuated in mid-childhood blood. Cord blood methylation at the PON1 locus predicted lower cognitive test scores measured during early childhood. Methylation at the PON1 locus was associated with PON1 expression in an independent set of cord blood samples. The observed persistent epigenetic disruption of the PON1 gene may modulate mercury toxicity in humans and might serve as a biomarker of exposure and disease susceptibility.Andres CardenasSheryl L. Rifas-ShimanGolareh AghaMarie-France HivertAugusto A. LitonjuaDawn L. DeMeoXihong LinChitra J. AmarasiriwardenaEmily OkenMatthew W. GillmanAndrea A. BaccarelliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andres Cardenas Sheryl L. Rifas-Shiman Golareh Agha Marie-France Hivert Augusto A. Litonjua Dawn L. DeMeo Xihong Lin Chitra J. Amarasiriwardena Emily Oken Matthew W. Gillman Andrea A. Baccarelli Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood
description	Abstract Prenatal exposure to mercury, a known neurotoxic metal, is associated with lower cognitive performance during childhood. Disruption of fetal epigenetic programming could explain mercury’s neurodevelopmental effects. We screened for epigenome-wide methylation differences associated with maternal prenatal blood mercury levels in 321 cord blood DNA samples and examined the persistence of these alterations during early (n = 75; 2.9–4.9 years) and mid-childhood (n = 291; 6.7–10.5 years). Among males, prenatal mercury levels were associated with lower regional cord blood DNA methylation at the Paraoxonase 1 gene (PON1) that persisted in early childhood and was attenuated in mid-childhood blood. Cord blood methylation at the PON1 locus predicted lower cognitive test scores measured during early childhood. Methylation at the PON1 locus was associated with PON1 expression in an independent set of cord blood samples. The observed persistent epigenetic disruption of the PON1 gene may modulate mercury toxicity in humans and might serve as a biomarker of exposure and disease susceptibility.
format	article
author	Andres Cardenas Sheryl L. Rifas-Shiman Golareh Agha Marie-France Hivert Augusto A. Litonjua Dawn L. DeMeo Xihong Lin Chitra J. Amarasiriwardena Emily Oken Matthew W. Gillman Andrea A. Baccarelli
author_facet	Andres Cardenas Sheryl L. Rifas-Shiman Golareh Agha Marie-France Hivert Augusto A. Litonjua Dawn L. DeMeo Xihong Lin Chitra J. Amarasiriwardena Emily Oken Matthew W. Gillman Andrea A. Baccarelli
author_sort	Andres Cardenas
title	Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood
title_short	Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood
title_full	Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood
title_fullStr	Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood
title_full_unstemmed	Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood
title_sort	persistent dna methylation changes associated with prenatal mercury exposure and cognitive performance during childhood
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/34d1f356b4af4b6da9e45b49926acd1a
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Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood

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