Renal function is associated with blood neurofilament light chain level in older adults

Abstract Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains un...

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Autores principales:	Shoshin Akamine, Noriko Marutani, Daisuke Kanayama, Shiho Gotoh, Riki Maruyama, Kanta Yanagida, Yukako Sakagami, Kohji Mori, Hiroyoshi Adachi, Junji Kozawa, Norikazu Maeda, Michio Otsuki, Takaaki Matsuoka, Hiromi Iwahashi, Iichiro Shimomura, Manabu Ikeda, Takashi Kudo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34d2655e12c04f6ead6868e613988c2d
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spelling	oai:doaj.org-article:34d2655e12c04f6ead6868e613988c2d2021-12-02T15:09:57ZRenal function is associated with blood neurofilament light chain level in older adults10.1038/s41598-020-76990-72045-2322https://doaj.org/article/34d2655e12c04f6ead6868e613988c2d2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-76990-7https://doaj.org/toc/2045-2322Abstract Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between blood NfL level and renal function among healthy participants undergoing a health check (n = 43, serum NfL) and patients with diabetes mellitus (n = 188, plasma NfL). All participants were 60 years of age or older; none were diagnosed with dementia. In each group, levels of blood NfL and serum creatinine significantly correlated (coefficient r = 0.50, 0.56). These associations remained statistically significant even after adjustment for age, sex, and body mass index. These findings indicate that blood NfL level might be partially affected by renal function. We recommend measuring renal function for a more precise evaluation of neuroaxonal damage, in particular, among older adults.Shoshin AkamineNoriko MarutaniDaisuke KanayamaShiho GotohRiki MaruyamaKanta YanagidaYukako SakagamiKohji MoriHiroyoshi AdachiJunji KozawaNorikazu MaedaMichio OtsukiTakaaki MatsuokaHiromi IwahashiIichiro ShimomuraManabu IkedaTakashi KudoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shoshin Akamine Noriko Marutani Daisuke Kanayama Shiho Gotoh Riki Maruyama Kanta Yanagida Yukako Sakagami Kohji Mori Hiroyoshi Adachi Junji Kozawa Norikazu Maeda Michio Otsuki Takaaki Matsuoka Hiromi Iwahashi Iichiro Shimomura Manabu Ikeda Takashi Kudo Renal function is associated with blood neurofilament light chain level in older adults
description	Abstract Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between blood NfL level and renal function among healthy participants undergoing a health check (n = 43, serum NfL) and patients with diabetes mellitus (n = 188, plasma NfL). All participants were 60 years of age or older; none were diagnosed with dementia. In each group, levels of blood NfL and serum creatinine significantly correlated (coefficient r = 0.50, 0.56). These associations remained statistically significant even after adjustment for age, sex, and body mass index. These findings indicate that blood NfL level might be partially affected by renal function. We recommend measuring renal function for a more precise evaluation of neuroaxonal damage, in particular, among older adults.
format	article
author	Shoshin Akamine Noriko Marutani Daisuke Kanayama Shiho Gotoh Riki Maruyama Kanta Yanagida Yukako Sakagami Kohji Mori Hiroyoshi Adachi Junji Kozawa Norikazu Maeda Michio Otsuki Takaaki Matsuoka Hiromi Iwahashi Iichiro Shimomura Manabu Ikeda Takashi Kudo
author_facet	Shoshin Akamine Noriko Marutani Daisuke Kanayama Shiho Gotoh Riki Maruyama Kanta Yanagida Yukako Sakagami Kohji Mori Hiroyoshi Adachi Junji Kozawa Norikazu Maeda Michio Otsuki Takaaki Matsuoka Hiromi Iwahashi Iichiro Shimomura Manabu Ikeda Takashi Kudo
author_sort	Shoshin Akamine
title	Renal function is associated with blood neurofilament light chain level in older adults
title_short	Renal function is associated with blood neurofilament light chain level in older adults
title_full	Renal function is associated with blood neurofilament light chain level in older adults
title_fullStr	Renal function is associated with blood neurofilament light chain level in older adults
title_full_unstemmed	Renal function is associated with blood neurofilament light chain level in older adults
title_sort	renal function is associated with blood neurofilament light chain level in older adults
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/34d2655e12c04f6ead6868e613988c2d
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Renal function is associated with blood neurofilament light chain level in older adults

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