Chronic Systemic Curcumin Administration Antagonizes Murine Sarcopenia and Presarcopenia

Curcumin administration attenuates muscle disuse atrophy, but its effectiveness against aging-induced, selective loss of mass or force (presarcopenia or asthenia/dynopenia), or combined loss (sarcopenia), remains controversial. A new systemic curcumin treatment was developed and tested in 18-month-o...

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Autores principales:	Luisa Gorza, Elena Germinario, Lucia Tibaudo, Maurizio Vitadello, Chiara Tusa, Irene Guerra, Michela Bondì, Stefano Salmaso, Paolo Caliceti, Libero Vitiello, Daniela Danieli-Betto
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	senescence aging sarcopenia Grp94 gp96 nNOS Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/34d5771e7fd44739bd6de062110389ab
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spelling	oai:doaj.org-article:34d5771e7fd44739bd6de062110389ab2021-11-11T17:14:21ZChronic Systemic Curcumin Administration Antagonizes Murine Sarcopenia and Presarcopenia10.3390/ijms2221117891422-00671661-6596https://doaj.org/article/34d5771e7fd44739bd6de062110389ab2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11789https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Curcumin administration attenuates muscle disuse atrophy, but its effectiveness against aging-induced, selective loss of mass or force (presarcopenia or asthenia/dynopenia), or combined loss (sarcopenia), remains controversial. A new systemic curcumin treatment was developed and tested in 18-month-old C57BL6J and C57BL10ScSn male mice. The effects on survival, liver toxicity, loss of muscle mass and force, and satellite cell responsivity and commitment were evaluated after 6-month treatment. Although only 24-month-old C57BL10ScSn mice displayed age-related muscle impairment, curcumin significantly increased survival of both strains (+20–35%), without signs of liver toxicity. Treatment prevented sarcopenia in soleus and presarcopenia in EDL of C57BL10ScSn mice, whereas it did not affect healthy-aged muscles of C57BL6J. Curcumin-treated old C57BL10ScSn soleus preserved type-1 myofiber size and increased type-2A one, whereas EDL maintained adult values of total myofiber number and fiber-type composition. Mechanistically, curcumin only partially prevented the age-related changes in protein level and subcellular distribution of major costamere components and regulators. Conversely, it affected satellite cells, by maintaining adult levels of myofiber maturation in old regenerating soleus and increasing percentage of isolated, MyoD-positive satellite cells from old hindlimb muscles. Therefore, curcumin treatment successfully prevents presarcopenia and sarcopenia development by improving satellite cell commitment and recruitment.Luisa GorzaElena GerminarioLucia TibaudoMaurizio VitadelloChiara TusaIrene GuerraMichela BondìStefano SalmasoPaolo CalicetiLibero VitielloDaniela Danieli-BettoMDPI AGarticlesenescenceagingsarcopeniaGrp94gp96nNOSBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11789, p 11789 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	senescence aging sarcopenia Grp94 gp96 nNOS Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	senescence aging sarcopenia Grp94 gp96 nNOS Biology (General) QH301-705.5 Chemistry QD1-999 Luisa Gorza Elena Germinario Lucia Tibaudo Maurizio Vitadello Chiara Tusa Irene Guerra Michela Bondì Stefano Salmaso Paolo Caliceti Libero Vitiello Daniela Danieli-Betto Chronic Systemic Curcumin Administration Antagonizes Murine Sarcopenia and Presarcopenia
description	Curcumin administration attenuates muscle disuse atrophy, but its effectiveness against aging-induced, selective loss of mass or force (presarcopenia or asthenia/dynopenia), or combined loss (sarcopenia), remains controversial. A new systemic curcumin treatment was developed and tested in 18-month-old C57BL6J and C57BL10ScSn male mice. The effects on survival, liver toxicity, loss of muscle mass and force, and satellite cell responsivity and commitment were evaluated after 6-month treatment. Although only 24-month-old C57BL10ScSn mice displayed age-related muscle impairment, curcumin significantly increased survival of both strains (+20–35%), without signs of liver toxicity. Treatment prevented sarcopenia in soleus and presarcopenia in EDL of C57BL10ScSn mice, whereas it did not affect healthy-aged muscles of C57BL6J. Curcumin-treated old C57BL10ScSn soleus preserved type-1 myofiber size and increased type-2A one, whereas EDL maintained adult values of total myofiber number and fiber-type composition. Mechanistically, curcumin only partially prevented the age-related changes in protein level and subcellular distribution of major costamere components and regulators. Conversely, it affected satellite cells, by maintaining adult levels of myofiber maturation in old regenerating soleus and increasing percentage of isolated, MyoD-positive satellite cells from old hindlimb muscles. Therefore, curcumin treatment successfully prevents presarcopenia and sarcopenia development by improving satellite cell commitment and recruitment.
format	article
author	Luisa Gorza Elena Germinario Lucia Tibaudo Maurizio Vitadello Chiara Tusa Irene Guerra Michela Bondì Stefano Salmaso Paolo Caliceti Libero Vitiello Daniela Danieli-Betto
author_facet	Luisa Gorza Elena Germinario Lucia Tibaudo Maurizio Vitadello Chiara Tusa Irene Guerra Michela Bondì Stefano Salmaso Paolo Caliceti Libero Vitiello Daniela Danieli-Betto
author_sort	Luisa Gorza
title	Chronic Systemic Curcumin Administration Antagonizes Murine Sarcopenia and Presarcopenia
title_short	Chronic Systemic Curcumin Administration Antagonizes Murine Sarcopenia and Presarcopenia
title_full	Chronic Systemic Curcumin Administration Antagonizes Murine Sarcopenia and Presarcopenia
title_fullStr	Chronic Systemic Curcumin Administration Antagonizes Murine Sarcopenia and Presarcopenia
title_full_unstemmed	Chronic Systemic Curcumin Administration Antagonizes Murine Sarcopenia and Presarcopenia
title_sort	chronic systemic curcumin administration antagonizes murine sarcopenia and presarcopenia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/34d5771e7fd44739bd6de062110389ab
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Chronic Systemic Curcumin Administration Antagonizes Murine Sarcopenia and Presarcopenia

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